[Baker JG, Hill SJ, Summers RJ. Evolution of β-blockers: from anti-anginal drugs to ligand-directed signalling. Trends Pharmacol Sci. 2011;32:227-234. 10.1016/j.tips.2011.02.010]Search in Google Scholar
[Ballesteros JA, Weinstein H. Integrated methods for the construction of threedimensional models and computational probing of structure-function relationship in Gprotein coupled receptors. Methods Neurosci. 1995;23:366-428 ]Search in Google Scholar
[Borchard U. Pharmacological properties of β-adrenoceptor blocking drugs. J Clin Bas Cadiol. 1998;1:5-9. ]Search in Google Scholar
[Čižmarikova R, Račanska E, Hroboňova K, Lehotay J, Aghova Y, Halešova D. Synthesis and pharmacological activity and chromatographic separation of novel potential β-blockers of the aryloxyaminopropanol type. Pharmazie. 2003;58:237-241. ]Search in Google Scholar
[Heilker R, Wolff M, Tautermann ChS, Bieler M. G-protein-coupled receptor-focused drug discovery using a target class platform approach. Drug Discov Today. 2009;14:231-240. 10.1016/j.drudis.2008.11.011]Search in Google Scholar
[Hieble JP. Adrenoceptors subclassification: an approach to improved cardiovascular therapeutics. Pharmacochem Lib. 2000;31:163-171. 10.1016/S0165-7208(00)80014-8]Search in Google Scholar
[Horn F, Weare J, Beukers MW, et al. GPCRDB: an information system for G proteincoupled receptors. Nucleic Acids Res. 1998;26:275-279. 10.1093/nar/26.1.2751471949399852]Search in Google Scholar
[Jaakola VP, IjzermanAP. The crystallographic structure of the adenosine A2A receptor in high-affinity antagonist-bound state: implication for GPCR drug screening and design. Curr Opinion Struct Biol. 2010;20:401-414. 10.1016/j.sbi.2010.05.00220538452]Search in Google Scholar
[Jacobson KA, Constanzi S. New insights for drug design from the X-ray crystallographic structure of G-protein-coupled receptors. Mol Pharmacol. 2012;82:361-371. 10.1124/mol.112.079335342270722695719]Search in Google Scholar
[Johannes A, Kellershohn K, Mohr-Adra M, et al. Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity. FASEB. 2009;23:442-450. 10.1096/fj.08-11475118842964]Search in Google Scholar
[Okada T, Le Trong I, Fox BA, Behnke CA, Stenkamp RE, Palczewski K. X-ray diffraction analysis of three-dimensional crystals of bovine rhodopsin obtained from mixed micelles. J Struct Biol. 2000;130:73-80. 10.1006/jsbi.1999.420910806093]Search in Google Scholar
[Peeters MC, van Westen GJP, Li Q, IJzerman AP. Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and activation. Trends Pharmacol Sci. 2011;32:35-42.10.1016/j.tips.2010.10.00121075459]Search in Google Scholar
[Rasmussen S, Choi H, Rosenbaum D, et al. Crystal structure of the human β2 adrenergic G-protein-coupled receptor. Nature. 2007;450:383-387. 10.1038/nature0632517952055]Search in Google Scholar
[Shoichet BK, McGovern SL, Wei B, Itwin J. Lead discovery using molecular docking. Curr Opinion Chem Biol. 2002;6:439-446. 10.1016/S1367-5931(02)00339-3]Search in Google Scholar
[Sybyl. Molecular Modeling Software Package, Tripos mc., St. Louis MO 63144 USA, 2011. ]Search in Google Scholar
[Topiol S, Sabio M. X-ray structure breakthroughs in the GPCR transmembrane region. Biochem Pharmacol. 2009;78:11-20. 10.1016/j.bcp.2009.02.01219447219]Search in Google Scholar
[Warne T, Serrano-Vega M, Baker J, et al. Structure of a β1 adrenergic G-proteincoupled receptor. Nature. 2008;454:486-491. 10.1038/nature07101292305518594507]Search in Google Scholar
[Warne T, Moukhametzianov R, Baker JG, et al. The structural basis for agonist and partial agonist action on a β1-adrenergic receptor. Nature. 2011;469:241-244. 10.1038/nature09746302314321228877]Search in Google Scholar
[Warne T, Edwards PC, Leslie AGW, Tate C. Crystal structures of stabilized β1- adrenoceptor bound to the biased agonists bucindolol and carvedilol. Structure. 2012;20:841-849.10.1016/j.str.2012.03.014338400322579251]Search in Google Scholar