<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Using rat paw dextran- and/or carageenan-induced edemas, the antiinflammatory activity of copper(II) and zinc(II) benzene-1,4-diylbis(oxyacetates) (compexes <bold>1c</bold> and <bold>1z</bold>) and free benzen-1,4-diylbis(oxyacetic)acid (<bold>1a</bold>) and their equimolar mixtures (<bold>1cz, 1ac</bold> and <bold>12az</bold>) were evaluated plethysmometrically. All the tested compounds were administered intraperitoneally in the single dose 50μmol/kg of body weight (calculated for the carboxylate fragment) 30 minutes before injecting the irritant. The antiphlogistic activity of the compounds (expressed as a mean edema reduction) was found as: <bold>1a</bold> 27.6 % / -23,0 % &lt; <bold>1c</bold> 44.2 % / 34.7 &lt; <bold>1z</bold> 69.2 % / 30.3 % &lt; <bold>1cz</bold> 59.7 % / 67.0 % &lt; <bold>1ac</bold> 53.1 % / 77.6 % &lt; <bold>1az</bold> 83.8 % / 85.5 %. The relationships between the coordination-chemical properties and the biological effects on the corresponding compounds are discussed.</p></abstract>

Using rat paw dextran- and/or carageenan-induced edemas, the antiinflammatory activity of copper(II) and zinc(II) benzene-1,4-diylbis(oxyacetates) (compexes 1c and 1z) and free benzen-1,4-diylbis(oxyacetic)acid (1a) and their equimolar mixtures (1cz, 1ac and 12az) were evaluated plethysmometrically. All the tested compounds were administered intraperitoneally in the single dose 50μmol/kg of body weight (calculated for the carboxylate fragment) 30 minutes before injecting the irritant. The antiphlogistic activity of the compounds (expressed as a mean edema reduction) was found as: 1a 27.6 % / -23,0 % < 1c 44.2 % / 34.7 < 1z 69.2 % / 30.3 % < 1cz 59.7 % / 67.0 % < 1ac 53.1 % / 77.6 % < 1az 83.8 % / 85.5 %. The relationships between the coordination-chemical properties and the biological effects on the corresponding compounds are discussed.

Evaluation of potential antiinflammatory activity of copper (ii) and zinc(ii) benzene-1, 4-diylbis(oxyacetates), free benzene-1, 4-diylbis(oxyacetic)acid and their mixtures in rats

Department of Pharmacology and Toxicology, Comenius University, Bratislava, Slovak Republic

Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic

European Pharmaceutical Journal

Using rat paw dextran- and/or carageenan-induced edemas, the antiinflammatory activity of copper(II) and zinc(II) benzene-1,4-diylbis(oxyacetates) (compexes 1c...

Evaluation of potential antiinflammatory activity of copper (ii) and zinc(ii) benzene-1, 4-diylbis(oxyacetates), free benzene-1, 4-diylbis(oxyacetic)acid and their mixtures in rats

Publié en ligne: 25 nov. 2011

Pages: 81 - 86

DOI: https://doi.org/10.2478/v10219-011-0009-x

Mots clés
copper(II) and zinc(II) complexes mixtures, rat paw carageenan- and dextran-induced edemas, anti-inflammatory activity

This content is open access.

Evaluation of potential antiinflammatory activity of copper (ii) and zinc(ii) benzene-1, 4-diylbis(oxyacetates), free benzene-1, 4-diylbis(oxyacetic)acid and their mixtures in rats

Publié en ligne: 25 nov. 2011

Pages: 81 - 86

DOI: https://doi.org/10.2478/v10219-011-0009-x

Mots cléscopper(II) and zinc(II) complexes mixtures, rat paw carageenan- and dextran-induced edemas, anti-inflammatory activity

This content is open access.

Mots clés
copper(II) and zinc(II) complexes mixtures, rat paw carageenan- and dextran-induced edemas, anti-inflammatory activity