[Ichimura M. Kase H. A new cyclic nucleotide phosphodiesterase isoenzyme expressed in the T-lyphocyte cell lines. Biochem Biophys Res Commun 1993; 193: 985-90.10.1006/bbrc.1993.1722]Search in Google Scholar
[Nakata A, Ogawa K, Sasaki T, Koyama N, Wada K, Kotera J, Kokkawa H, Omori K, Kaminuma O. Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors. Clin Exp Immunol 2002; 128: 460-6.10.1046/j.1365-2249.2002.01856.x]Search in Google Scholar
[Jones NA, Leport M, Holand T, Vos T, MOrgan M, Fink M, Pruniaux MP, Berthelier C, O'Connor BJ, Bertrand C, Page CP. Phosphodiesterase (PDE) 7 in inflammatory cells from patients with asthma and COPD. Pulm Pharmacol Therap 2007; 20: 60-8.10.1016/j.pupt.2005.11.010]Search in Google Scholar
[Kadoshima-Yamaoka K, Murakawa M, Goto M, Tanaka Y, Inoue H, Murafuji H, Nagahira A, Hayashi Y, Kagahira K, Miura K, Nakatsuka T, Chamoto K, Fukuda Y, Nishimura T. ASB16165, a novel inhibitor for phos-phodiesterase 7A (PDE7A), supresses IL-12-induced IFN- production by mouse activated T lymphocytes. Immunol Letters 2009; 122: 193-7.10.1016/j.imlet.2009.01.004]Search in Google Scholar
[Mokry J, Nosalova G, Mokra D. Influence of xanthine derivatives on cough and airway reactivity in guinea pigs. J Physiol Pharmacol 2009; 60 (Suppl 5): 87-91.]Search in Google Scholar
[Mokra D, Mokry J. Meconium aspiration syndrome. From pathomechanisms to treatment. 1st ed. Nova Science Publishers: New York, 2010, 130 p.]Search in Google Scholar
[Nosalova G, Mokry J. The mechanism of action of xanthine derivatives and suppression of cough. Acta Med Mart 2001; 1: 14-8.]Search in Google Scholar
[Usmani OS, Belvisi MG, Patel HJ, et al. Theobromine inhibits sensory nerve activation and cough. FASEB J 2004: 2-16.10.1096/fj.04-1990fje]Search in Google Scholar
[Antoniu SA. Roflumilast for the treatment of chronic obstructive pulmonary disease. Curr Opin Investig Drugs 2006; 7: 412-7.]Search in Google Scholar
[Lipworth BJ. Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease. Lancet 2005; 365: 167-75.10.1016/S0140-6736(05)17708-3]Search in Google Scholar
[Spina D, Landells LJ, Page CP. The role of theophylline and phosphodiesterase4 isoenzyme inhibitors as anti-inflammatory drugs. Clin Exp Allergy 1998; 28 (Suppl 3): 24-34.]Search in Google Scholar
[Matera MG, Page CP, Cazzola M. Novel bronchodilators for the treatment of chronic obstructive pulmonary disease. Trends Pharmacol Sci 2011; 32(8): 495-505.10.1016/j.tips.2011.04.00321683458]Search in Google Scholar
[Chung KF. Phosphodiesterase inhibitors in airways disease. Eur J Pharmacol 2006; 533: 110-7.10.1016/j.ejphar.2005.12.05916458289]Search in Google Scholar
[Spina D. PDE4 inhibitors: current status. Br J Pharmacol 2008; 155: 308-15.10.1038/bjp.2008.307256789218660825]Search in Google Scholar
[Bender AT, Beavo JA. Cyclic nucleotide phosphodiesterases: Molecular regulation to clinical use. Pharmacol Rev 2006; 58: 488-520.10.1124/pr.58.3.516968949]Search in Google Scholar
[Karish SB, Gagnon JM. The potential role of roflumilast: the new phosphodiesterase-4 inhibitor. Ann Pharmacother 2006; 40: 1096-104.10.1345/aph.1E651]Search in Google Scholar
[Fabbri LM, Beghe B, Yasothan U, Kirkpatrick P. Roflumilast. Nature Reviews Drug Discovery 2010; 9: 761-762.10.1038/nrd3276]Search in Google Scholar
[Giembycz MA, Field SK. Roflumilast: first phosphodiesterase 4 inhibitor approved for treatment of COPD. Drug Des Devel Ther 2010; 4: 147-158.]Search in Google Scholar
[Mokry J, Mokra D, Nosalova G, Beharkova M, Feherova Z. Influence of selective inhibitors of phosphodiesterase 3 and 4 on cough and airway reactivity. J Physiol Pharmacol 2008; 59 (suppl. 6): 473-82.]Search in Google Scholar
[Smith SJ, Cieslinski LB, Newton R, Donnelly LE, Fenwick PS, Nicholson AG, Barnes PJ, Barnette MS, Giembycz MA. Discovery of BRL 50481 [3-(N, N-dimethylsulfonamido)-4-methyl-nitrobenzene], a Selective Inhibitor of Phosphodiesterase 7: In Vitro Studies in Human Monocytes, Lung Macrophages, and CD8+ T-Lymphocytes. Molecular Pharmacology 2004; 66(6): 1679-1689.10.1124/mol.104.002246]Search in Google Scholar
[Morales-Garcia JA, Redondo M, Alonso-Gil S, Gil C, Perez C, Martinez A, Santos A, Perez-Castillo A. Phosphodiesterase 7 Inhibition Preserves Dopaminergic Neurons in Cellular and Rodent Models of Parkinson Disease. PLoS ONE 2011; 6(2): e17240.10.1371/journal.pone.0017240]Search in Google Scholar
[Franova S, Nosalova G, Pechanova O, Sutovska M. Red wine polyphenolic compounds inhibit tracheal smooth muscle contraction during allergen-induced hyperreactivity of the airways. J Pharm Pharmacol 2007; 59: 727-32.10.1211/jpp.59.5.0014]Search in Google Scholar
[Sutovska M, Franova S, Sutovsky J. The influence of animal species on the relationship between ATP-sensitive potassium ion channels and defense reflexes of the airways. Bratisl Med J 2009; 110 (5), 269-275.]Search in Google Scholar
[Strapkova A, Nosalova G, Banovcin P, Giacova D. Changes in airway smooth muscle reactivity after exposure to toluene. Stud Pneumol Phthiseol 1995; 55: 263-71.]Search in Google Scholar
[Javorka K, Calkovska A, Mokra D, Tonhajzerova I. Medical Physiology. Laboratory Manual. Comenius University, Bratislava, 2006, p. 143.]Search in Google Scholar
[Beeh KM, Beier J, Lerch C, Schulz AK, Buhl R. Effects of Piclamilast, a Selective Phosphodiesterase-4 Inhibitor, on Oxidative Burst of Sputum Cells From Mild Asthmatics and Stable COPD Patients. Lung 2004; 182: 369-77.10.1007/s00408-004-2518-z]Search in Google Scholar
[Giembycz MA. Phosphodiesterase-4: Selective and Dual-Specificity Inhibitors for the Therapy of Chronic Obstructive Pulmonary Disease. Proc American Thor Soc 2005b; 2: 326-33.10.1513/pats.200504-041SR]Search in Google Scholar
[Rabe KF, Bateman ED, O'Donnel D, Witte S, Bredenbroker D, Bethke TD. Roflumilast: an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial. Lancet 2005; 366: 563-71.10.1016/S0140-6736(05)67100-0]Search in Google Scholar
[Ghosh R, Sawant O, Ganpathy P, Pitre S, Kadam VJ. Phosphodiesterase inhibitors: their role and implications. Int J PharmTech Res 2009; 1(4): 1148-60.]Search in Google Scholar
[Paterniti I, Mazzon E, Gil C, Impellizzeri D, Palomo V, Redondo M, Perez DI, Esposito E, Martinez A, Cuzzocrea S. PDE7 inhibitors: new potential drugs for the therapy of spinal cord injury. PLoS ONE 2011; 6(1): e15937.10.1371/journal.pone.0015937303152421297958]Search in Google Scholar
[Guo J, Watson A, Kempson J, Carlsen M, Barbosa J, Stebbins K, Lee D, Dodd J, Nadler SG, McKinnon M, Barrish J, Pitts WJ. Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation. Bioorganic Medicinal Chmistry Letters 2009; 19: 1935-8.10.1016/j.bmcl.2009.02.06019272774]Search in Google Scholar
[Pitts WJ, Vaccaro W, Huynh T, Leftheris K, Roberge JY, Barbosa J, Guo J, Brown B, Watson A, Donaldson K, Starling GC, Kiener PA, Poss MA, Dodd JH, Barrish JC. Identification of purine inhibitors of phosphodiesterase 7 (PDE7). Bioorganic Medicinal Chemistry Letters 2004; 14: 2955-8.10.1016/j.bmcl.2004.03.02115125967]Search in Google Scholar
[Fortin M, D'Anjou H, Higgins ME, Gougeon J, Aube P, Moktefi K, Mouissi S, Seguin S, Seguin R, Renzi PM, Paquet L, Ferrari N. A multi-target antisense approach against PDE4 and PDE7 reduces smoke-induced lung inflammation in mice. Respiratory Res 2009; 10:39.10.1186/1465-9921-10-39269643719457265]Search in Google Scholar
[Giembycz MA. Life after PDE4: overcoming adverse events with dual-specificity phosphodiesterase inhibitors. Curr Opin Pharmacol 2005a; 5: 238-44.10.1016/j.coph.2005.04.00115907909]Search in Google Scholar