<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Meconium aspiration syndrome (MAS) is a major cause of respiratory distress in both the term and post-term neonates. Obstruction of the airways, dysfunction of pulmonary surfactant, inflammation, lung edema, pulmonary vasoconstriction and bronchoconstriction participate in the pathogenesis of this disorder. Since the inflammatory changes associated with meconium aspiration cause a severe impairment of the lung parenchyma including surfactant and influence the reactivity of both vascular and airway smooth muscle, administration of anti-inflammatory drugs may be of benefit also in the management of MAS. This article reviews effects of various anti-inflammatory drugs used in experimental models of MAS as well as in the treatment of newborns with meconium aspiration.</p></abstract>

Meconium aspiration syndrome (MAS) is a major cause of respiratory distress in both the term and post-term neonates. Obstruction of the airways, dysfunction of pulmonary surfactant, inflammation, lung edema, pulmonary vasoconstriction and bronchoconstriction participate in the pathogenesis of this disorder. Since the inflammatory changes associated with meconium aspiration cause a severe impairment of the lung parenchyma including surfactant and influence the reactivity of both vascular and airway smooth muscle, administration of anti-inflammatory drugs may be of benefit also in the management of MAS. This article reviews effects of various anti-inflammatory drugs used in experimental models of MAS as well as in the treatment of newborns with meconium aspiration.

Anti-Inflammatory Drugs in the Treatment of Meconium Aspiration Syndrome

Department of Physiology, Comenius University, Martin, Slovak Republic

Department of Pharmacology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovak Republic

Acta Medica Martiniana

{"article-title":"Anti-Inflammatory Drugs in the Treatment of Meconium Aspiration Syndrome"}

Meconium aspiration syndrome (MAS) is a major cause of respiratory distress in both the term and post-term neonates. Obstruction of the airways, dysfunction of...

Anti-Inflammatory Drugs in the Treatment of Meconium Aspiration Syndrome

Publié en ligne: 03 mars 2011

Pages: 15 - 23

DOI: https://doi.org/10.2478/v10201-011-0007-7

Mots clés
meconium aspiration syndrome, inflammation, anti-inflammatory drugs, newborn, animal model

This content is open access.

Anti-Inflammatory Drugs in the Treatment of Meconium Aspiration Syndrome

Publié en ligne: 03 mars 2011

Pages: 15 - 23

DOI: https://doi.org/10.2478/v10201-011-0007-7

Mots clésmeconium aspiration syndrome, inflammation, anti-inflammatory drugs, newborn, animal model

This content is open access.

Mots clés
meconium aspiration syndrome, inflammation, anti-inflammatory drugs, newborn, animal model