<abstract xmlns="http://www.w3.org/1999/xhtml"><p> We provide some details of the implementation of optimal design algorithm in the PkStaMp library which is intended for constructing optimal sampling schemes for pharmacokinetic (PK) and pharmacodynamic (PD) studies. We discuss different types of approximation of individual Fisher information matrix and describe a user-defined option of the library.</p></abstract>

We provide some details of the implementation of optimal design algorithm in the PkStaMp library which is intended for constructing optimal sampling schemes for pharmacokinetic (PK) and pharmacodynamic (PD) studies. We discuss different types of approximation of individual Fisher information matrix and describe a user-defined option of the library.

Optimal design for population pk/pd models

Vertex Pharmaceuticals 130 Waverly Street Cambridge, MA 02139 U.S.A.

Institute for Systems Analysis Prospect 60-letia Octiabria, 9 Moscow 117312 RUSSIA

Tatra Mountains Mathematical Publications

{"article-title":"Optimal design for population pk/pd models"}

We provide some details of the implementation of optimal design algorithm in the PkStaMp library which is intended for constructing optimal sampling schemes...

Optimal design for population pk/pd models

Publié en ligne: 13 nov. 2012

Pages: 115 - 130

DOI: https://doi.org/10.2478/v10127-012-0012-1

Mots clés
optimal model-based design, Fisher information matrix, D-optimality, PK/PD models, compartmental models.

This content is open access.

Optimal design for population pk/pd models

Publié en ligne: 13 nov. 2012

Pages: 115 - 130

DOI: https://doi.org/10.2478/v10127-012-0012-1

Mots clésoptimal model-based design, Fisher information matrix, D-optimality, PK/PD models, compartmental models.

This content is open access.

Mots clés
optimal model-based design, Fisher information matrix, D-optimality, PK/PD models, compartmental models.