<abstract xmlns="http://www.w3.org/1999/xhtml"> The aim of the present study was to assess the effect of iron and copper consumption on weight gain and development of oxidative stress in adipose tissue of rats. Control rats obtained pure drinking water. Iron-treated groups of animals obtained FeSO4•12Н2О with drinking water in concentrations of 3 and 6 mg/l, while copper-treated rats obtained CuSO4 in concentrations of 4.88 and 9.76 mg/l. The animals of the 6th group received a mixture of FeSO4•12Н2О and CuSO4 in the respective concentrations of 3 and 4.88 mg/l in drinking water. All animals received a standard chow. The final weight of rats from all the experimental groups, especially in those obtaining the combination of iron and cooper, exceeded the control values. Maximal weight of fat pads was observed in animals receiving drinking water with 3 mg/l FeSO4•12Н2О, 4.88 and 9.76 mg/l CuSO4, and the mixture of FeSO4•12Н2О and CuSO4. The maximal intensity of free radical processes, as estimated by the concentration of fluorescent modified amino acids and the intensity of chemiluminescence in adipose tissue homogenates, was observed in rats obtaining iron in the concentration of 3 mg/l in the drinking water.</abstract>

The aim of the present study was to assess the effect of iron and copper consumption on weight gain and development of oxidative stress in adipose tissue of rats. Control rats obtained pure drinking water. Iron-treated groups of animals obtained FeSO4•12Н2О with drinking water in concentrations of 3 and 6 mg/l, while copper-treated rats obtained CuSO4 in concentrations of 4.88 and 9.76 mg/l. The animals of the 6th group received a mixture of FeSO4•12Н2О and CuSO4 in the respective concentrations of 3 and 4.88 mg/l in drinking water. All animals received a standard chow. The final weight of rats from all the experimental groups, especially in those obtaining the combination of iron and cooper, exceeded the control values. Maximal weight of fat pads was observed in animals receiving drinking water with 3 mg/l FeSO4•12Н2О, 4.88 and 9.76 mg/l CuSO4, and the mixture of FeSO4•12Н2О and CuSO4. The maximal intensity of free radical processes, as estimated by the concentration of fluorescent modified amino acids and the intensity of chemiluminescence in adipose tissue homogenates, was observed in rats obtaining iron in the concentration of 3 mg/l in the drinking water.

Influence of iron and copper consumption on weight gain and oxidative stress in adipose tissue of Wistar rats

Department of Biochemistry, Orenburg State Medical Academy Sovetskaya Street 6, Orenburg 460000, Russia TEL.: +7-961-937-81-98

Interdepartmental Biochemical Laboratory, Orenburg State Medical Academy, Orenburg, Russia

Department of Human Pathology, 1st Orenburg Regional Clinical Hospital, Orenburg, Russia

Department of general and communal hygiene and human ecology, Orenburg State Medical Academy, Orenburg, Russia

Department of Biochemistry, Orenburg State Medical Academy, Orenburg, Russia

Interdisciplinary Toxicology

The aim of the present study was to assess the effect of iron and copper consumption on weight gain and development of oxidative stress in adipose tissue of...

Influence of iron and copper consumption on weight gain and oxidative stress in adipose tissue of Wistar rats

Publié en ligne: 16 janv. 2013

Pages: 127 - 132

DOI: https://doi.org/10.2478/v10102-012-0021-6

This content is open access.