<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Individual characteristics of human nature (<italic>e.g.</italic> introversion, extroversion, mood, activity, adaptability, aggressiveness, social ability, anxiety) do not need to be primarily innate. They can be determined by the action of various influences and their interactions on functional development of the brain. There is ample epidemiological and experimental evidence that chemical and/or physical factors acting during sensitive time windows of the brain development can cause mental, behavioral, emotional and/or cognitive disorders. Environmental pollutants, addictive substances, drugs, malnutrition, excessive stress and/or hypoxia-ischemia were reported to induce functional maldevelopment of the brain with consequent neurobehavioral disorders. The article provides review on most significant neurobehavioral manifestations of developmental impairment of the brain during prenatal, perinatal and early postnatal period. The most known adverse factors causing developmental neurobehavioral dysfunctions in humans as well as in experimental animals are discussed.</p></abstract>

Individual characteristics of human nature (e.g. introversion, extroversion, mood, activity, adaptability, aggressiveness, social ability, anxiety) do not need to be primarily innate. They can be determined by the action of various influences and their interactions on functional development of the brain. There is ample epidemiological and experimental evidence that chemical and/or physical factors acting during sensitive time windows of the brain development can cause mental, behavioral, emotional and/or cognitive disorders. Environmental pollutants, addictive substances, drugs, malnutrition, excessive stress and/or hypoxia-ischemia were reported to induce functional maldevelopment of the brain with consequent neurobehavioral disorders. The article provides review on most significant neurobehavioral manifestations of developmental impairment of the brain during prenatal, perinatal and early postnatal period. The most known adverse factors causing developmental neurobehavioral dysfunctions in humans as well as in experimental animals are discussed.

Neurobehavioral manifestations of developmental impairment of the brain

Institute of Experimental Pharmacology & Toxicology, Slovak Academy of Sciences, SK-84104 Bratislava, Slovakia

Interdisciplinary Toxicology

{"article-title":"Neurobehavioral manifestations of developmental impairment of the brain"}

Individual characteristics of human nature (e.g. introversion, extroversion, mood, activity, adaptability, aggressiveness, social ability, anxiety) do not need...

Neurobehavioral manifestations of developmental impairment of the brain

Publié en ligne: 30 juil. 2010

Pages: 59 - 67

DOI: https://doi.org/10.2478/v10102-010-0012-4

Mots clés
neurobehavioral dysfunctions, brain development, cognitive disorder, mental disorder, emotional disorder, behavioral disorder, developmental neurotoxicity, environmental factors

This content is open access.

Neurobehavioral manifestations of developmental impairment of the brain

Publié en ligne: 30 juil. 2010

Pages: 59 - 67

DOI: https://doi.org/10.2478/v10102-010-0012-4

Mots clésneurobehavioral dysfunctions, brain development, cognitive disorder, mental disorder, emotional disorder, behavioral disorder, developmental neurotoxicity, environmental factors

This content is open access.

Mots clés
neurobehavioral dysfunctions, brain development, cognitive disorder, mental disorder, emotional disorder, behavioral disorder, developmental neurotoxicity, environmental factors