<abstract xmlns="http://www.w3.org/1999/xhtml"><p> One of the key issues of organogenesis is the understanding of mechanisms underlying the differentiation of progenitor cells into more specialized cells of individual tissues. Recent transcriptomic and proteomic approaches of molecular biology have led to the identification of several factors and mechanisms regulating morphogenesis at the genetic level which affect the function of already differentiated cells. In the last few years, several reports about osteoblastogenesis have been published. This review presents recent findings on the role of the most important transcription factors supporting bone formation.</p></abstract>

One of the key issues of organogenesis is the understanding of mechanisms underlying the differentiation of progenitor cells into more specialized cells of individual tissues. Recent transcriptomic and proteomic approaches of molecular biology have led to the identification of several factors and mechanisms regulating morphogenesis at the genetic level which affect the function of already differentiated cells. In the last few years, several reports about osteoblastogenesis have been published. This review presents recent findings on the role of the most important transcription factors supporting bone formation.

The Most Important Transcriptional Factors of Osteoblastogenesis

Department of Biophysics and Human Physiology, Medical University of Warsaw

Medical Journal of Cell Biology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"The Most Important Transcriptional Factors of Osteoblastogenesis"}

One of the key issues of organogenesis is the understanding of mechanisms underlying the differentiation of progenitor cells into more specialized cells of...

The Most Important Transcriptional Factors of Osteoblastogenesis

Publié en ligne: 15 oct. 2014

Pages: 17 - 28

DOI: https://doi.org/10.2478/v10052-010-0002-x

Mots clés
osteoblasts, transcriptional factors, Runx2, Osterix, osteoblastogenesis

© by Malgorzata Witkowska-Zimny

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The Most Important Transcriptional Factors of Osteoblastogenesis

Publié en ligne: 15 oct. 2014

Pages: 17 - 28

DOI: https://doi.org/10.2478/v10052-010-0002-x

Mots clésosteoblasts, transcriptional factors, Runx2, Osterix, osteoblastogenesis

© by Malgorzata Witkowska-Zimny

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
osteoblasts, transcriptional factors, Runx2, Osterix, osteoblastogenesis