The heat and moisture transport in multi-layer walls is analysed for five building units. Using the developed program, a typical of Latvian conditions temperature and relative humidity profiles in multi-layered constructions has been obtained and the indoor heat losses estimated. Consideration is also given to the risk of condensate formation and to the influence of moisture on the U-value. The created mathematical model allows forecasting the energy efficiency and sustainability of different technical solutions as refer to the heat and moisture transport in buildings.