<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Seminal plasma is a potential source of biomarkers for many disorders of the male reproductive system including male infertility. Knowledge of the peptide and protein components of seminal fluid is accumulating especially with the appearance of highthroughput MS-based techniques. Of special interest in the field of male infertility biomarkers, is the identification and characterization of differentially expressed proteins in seminal plasma of men with normal and impaired spermatogenesis. However, the data obtained until now is still quite heterogeneous and with small percentage of overlap between independent studies. Extensive comparative analysis of seminal plasma proteome is still needed in order to establish a potential link between seminal plasma proteins and male infertility.</p></abstract>

Seminal plasma is a potential source of biomarkers for many disorders of the male reproductive system including male infertility. Knowledge of the peptide and protein components of seminal fluid is accumulating especially with the appearance of highthroughput MS-based techniques. Of special interest in the field of male infertility biomarkers, is the identification and characterization of differentially expressed proteins in seminal plasma of men with normal and impaired spermatogenesis. However, the data obtained until now is still quite heterogeneous and with small percentage of overlap between independent studies. Extensive comparative analysis of seminal plasma proteome is still needed in order to establish a potential link between seminal plasma proteins and male infertility.

Human Seminal Plasma Proteome Study: a Search for Male Infertility Biomarkers

Research Centre for Genetic Engineering and Biotechnology “Georgi D. Efremov,” Macedonian Academy of Sciences and Arts, 1000 Skopje, Republic of Macedonia

Endocrinology and Metabolic Disorders Clinic, Faculty of Medicine, Skopje, Republic of Macedonia

Balkan Journal of Medical Genetics

{"article-title":"Human Seminal Plasma Proteome Study: a Search for Male Infertility Biomarkers"}

Seminal plasma is a potential source of biomarkers for many disorders of the male reproductive system including male infertility. Knowledge of the peptide and...

Human Seminal Plasma Proteome Study: a Search for Male Infertility Biomarkers

Publié en ligne: 22 déc. 2012

Pages: 35 - 38

DOI: https://doi.org/10.2478/v10034-012-0016-9

This content is open access.