<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>We compared individual trait variability in 65 male and 81 female patients with spina bifida occulta (SBO) or spina bifida aperta (SBA) against 170 male and 200 female subjects randomly selected Serbian subjects without these conditions. Variability was evaluated by direct observation of 15 homozygous recessive traits (HRT), while gender was evaluated separately. Individual trait variations between genders in SBO patients (4/15 HRT) and in SBA patients (12/15 HRT) showed remarkable differences. Individual trait variations between the male control group and SBO (9/15 HRT), between the female control group and SBO (5/15 HRT), between the male control group and SBA (8/15 HRT), between the female control group and SBA (9/15 HRT), between male SBO and SBA patients (6/15 HRT), between female SBO and SBA patients (6/15 HRT), also indicated remarkable differences. These differences could be explained by different expression of genes that may contribute to expression of spina bifida (SB).</p></abstract>

We compared individual trait variability in 65 male and 81 female patients with spina bifida occulta (SBO) or spina bifida aperta (SBA) against 170 male and 200 female subjects randomly selected Serbian subjects without these conditions. Variability was evaluated by direct observation of 15 homozygous recessive traits (HRT), while gender was evaluated separately. Individual trait variations between genders in SBO patients (4/15 HRT) and in SBA patients (12/15 HRT) showed remarkable differences. Individual trait variations between the male control group and SBO (9/15 HRT), between the female control group and SBO (5/15 HRT), between the male control group and SBA (8/15 HRT), between the female control group and SBA (9/15 HRT), between male SBO and SBA patients (6/15 HRT), between female SBO and SBA patients (6/15 HRT), also indicated remarkable differences. These differences could be explained by different expression of genes that may contribute to expression of spina bifida (SB).

Individual Phenotype Trait Variability as Genetic Markers of Gender Susceptibility to Spina Bifida

Physical Medicine and Rehabilitation, University Children's Hospital, Belgrade, Serbia

School of Medicine, University of Belgrade, Belgrade, Serbia

Institute for Human Genetics, School of Medicine, University of Belgrade, Belgrade, Serbia

Pediatric Surgery, University Children's Hospital, Belgrade, Serbia

Cardiac Surgery Clinic, Clinical Center of Serbia, Belgrade, Serbia

Balkan Journal of Medical Genetics

We compared individual trait variability in 65 male and 81 female patients with spina bifida occulta (SBO) or spina bifida aperta (SBA) against 170 male and...

Individual Phenotype Trait Variability as Genetic Markers of Gender Susceptibility to Spina Bifida

Publié en ligne: 25 juil. 2011

Pages: 11 - 17

DOI: https://doi.org/10.2478/v10034-011-0012-5

Mots clés
Spina bifida (SB), Gender, Homozygous recessive traits (HRT), Variability

This content is open access.

Individual Phenotype Trait Variability as Genetic Markers of Gender Susceptibility to Spina Bifida

Publié en ligne: 25 juil. 2011

Pages: 11 - 17

DOI: https://doi.org/10.2478/v10034-011-0012-5

Mots clésSpina bifida (SB), Gender, Homozygous recessive traits (HRT), Variability

This content is open access.

Mots clés
Spina bifida (SB), Gender, Homozygous recessive traits (HRT), Variability