<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Single nucleotide polymorphisms (SNPs) have become a very powerful tool for molecular genetics studies. Public databases provide information on over 10 million polymorphisms in the human genome. The candidate gene approach and genomewide association studies through SNP analysis have opened a new avenue for defining the genetics of complex disorders. However, analysis of large numbers of SNPs is time-consuming, cost-intensive, and requires huge experimental and statistical resources in association studies. We have developed a web-based product that facilitates the processing and statistical analysis of SNP-genotyping data for casecontrol association studies and provides for custom design, a structured database and practical export layout. Here we describe the software product database and how it helps in high-speed comprehensive SNP analysis.</p></abstract>

Single nucleotide polymorphisms (SNPs) have become a very powerful tool for molecular genetics studies. Public databases provide information on over 10 million polymorphisms in the human genome. The candidate gene approach and genomewide association studies through SNP analysis have opened a new avenue for defining the genetics of complex disorders. However, analysis of large numbers of SNPs is time-consuming, cost-intensive, and requires huge experimental and statistical resources in association studies. We have developed a web-based product that facilitates the processing and statistical analysis of SNP-genotyping data for casecontrol association studies and provides for custom design, a structured database and practical export layout. Here we describe the software product database and how it helps in high-speed comprehensive SNP analysis.

Web-Based Software for Storage, Statistical Processing and Analysis of SNP Data in Studies on Complex Disorders

Department of Medical Genetics, Medical University, Sofia, Bulgaria

Department of Menagement and Marketing, Technical University, Varna, Bulgaria

Balkan Journal of Medical Genetics

Single nucleotide polymorphisms (SNPs) have become a very powerful tool for molecular genetics studies. Public databases provide information on over 10 million...

Web-Based Software for Storage, Statistical Processing and Analysis of SNP Data in Studies on Complex Disorders

Publié en ligne: 09 oct. 2009

Pages: 9 - 14

DOI: https://doi.org/10.2478/v10034-009-0004-x

Mots clés
Association study, High-throughput genotyping, Information technology (IT), Multifactorial (complex) disorders, Single nucleotide polymorphisms (SNPs), Web-based software

This content is open access.

Web-Based Software for Storage, Statistical Processing and Analysis of SNP Data in Studies on Complex Disorders

Publié en ligne: 09 oct. 2009

Pages: 9 - 14

DOI: https://doi.org/10.2478/v10034-009-0004-x

Mots clésAssociation study, High-throughput genotyping, Information technology (IT), Multifactorial (complex) disorders, Single nucleotide polymorphisms (SNPs), Web-based software

This content is open access.

Mots clés
Association study, High-throughput genotyping, Information technology (IT), Multifactorial (complex) disorders, Single nucleotide polymorphisms (SNPs), Web-based software