<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p><bold>Background.</bold> Light microscopic evaluation of cell morphology in preparations from urine or bladder washing containing exfoliated cells is a standard and primary method for the detection of bladder cancer and also malignancy from other parts of the urinary tract. The cytopathologic examination is a valuable method to detect an early recurrence of malignancy or new primary carcinoma during the follow-up of patients after the treatment of bladder cancer.</p><p><bold>Conclusions.</bold> Characteristic cellular and nuclear signs of malignancy indicate invasive or <italic>in situ</italic> urothelial carcinoma or high-grade papillary urothelial carcinoma. However, low sensitivity of the method reflects the unreliable cytopathologic diagnosis of low-grade urothelial neoplasms as cellular and nuclear signs of malignancy in these neoplasms are poorly manifested. Many different markers were developed to improve the diagnosis of bladder carcinoma on urinary samples. UroVysion™ test is among the newest and most promising tests. By the method of <italic>in situ</italic> hybridization one can detect specific cytogenetic changes of urothelial carcinoma.</p></abstract>

Background. Light microscopic evaluation of cell morphology in preparations from urine or bladder washing containing exfoliated cells is a standard and primary method for the detection of bladder cancer and also malignancy from other parts of the urinary tract. The cytopathologic examination is a valuable method to detect an early recurrence of malignancy or new primary carcinoma during the follow-up of patients after the treatment of bladder cancer.Conclusions. Characteristic cellular and nuclear signs of malignancy indicate invasive or in situ urothelial carcinoma or high-grade papillary urothelial carcinoma. However, low sensitivity of the method reflects the unreliable cytopathologic diagnosis of low-grade urothelial neoplasms as cellular and nuclear signs of malignancy in these neoplasms are poorly manifested. Many different markers were developed to improve the diagnosis of bladder carcinoma on urinary samples. UroVysion™ test is among the newest and most promising tests. By the method of in situ hybridization one can detect specific cytogenetic changes of urothelial carcinoma.

Urine and bladder washing cytology for detection of urothelial carcinoma: standard test with new possibilities

Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

Radiology and Oncology

Background. Light microscopic evaluation of cell morphology in preparations from urine or bladder washing containing exfoliated cells is a standard and primary...

Urine and bladder washing cytology for detection of urothelial carcinoma: standard test with new possibilities

Publié en ligne: 29 sept. 2010

Pages: 207 - 214

DOI: https://doi.org/10.2478/v10019-010-0042-8

Mots clés
cytology, urine, bladder washing, urothelial carcinoma

This content is open access.

Urine and bladder washing cytology for detection of urothelial carcinoma: standard test with new possibilities

Publié en ligne: 29 sept. 2010

Pages: 207 - 214

DOI: https://doi.org/10.2478/v10019-010-0042-8

Mots cléscytology, urine, bladder washing, urothelial carcinoma

This content is open access.

Mots clés
cytology, urine, bladder washing, urothelial carcinoma