<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>The dramatic pace in development of gene therapy over the past decades has made it a realistic alternative for the treatment of cancer. Radiotherapy, on the other hand, is one of the most commonly used and well established cancer treatment modalities. The latest improvements in the physical targeting ability of radiotherapy and understanding of the molecular mechanism involved in the cellular response to ionizing radiation have presented an opportunity to combine radiotherapy with gene therapy. This review article will focus on gene therapy strategies that can be used to enhance the effectiveness of radiotherapy, with an emphasis on transcriptional targeting approaches.</p></abstract>

The dramatic pace in development of gene therapy over the past decades has made it a realistic alternative for the treatment of cancer. Radiotherapy, on the other hand, is one of the most commonly used and well established cancer treatment modalities. The latest improvements in the physical targeting ability of radiotherapy and understanding of the molecular mechanism involved in the cellular response to ionizing radiation have presented an opportunity to combine radiotherapy with gene therapy. This review article will focus on gene therapy strategies that can be used to enhance the effectiveness of radiotherapy, with an emphasis on transcriptional targeting approaches.

Targeted gene therapy in radiotherapy

Department of Experimental Oncology, Institute of Oncology Ljubljana, Slovenia

Radiology and Oncology

{"article-title":"Targeted gene therapy in radiotherapy"}

The dramatic pace in development of gene therapy over the past decades has made it a realistic alternative for the treatment of cancer. Radiotherapy, on the...

Targeted gene therapy in radiotherapy

Publié en ligne: 08 sept. 2008

Pages: 115 - 135

DOI: https://doi.org/10.2478/v10019-008-0009-1

Mots clés
gene therapy, radiotherapy, transcriptional targeting

This content is open access.

Targeted gene therapy in radiotherapy

Publié en ligne: 08 sept. 2008

Pages: 115 - 135

DOI: https://doi.org/10.2478/v10019-008-0009-1

Mots clésgene therapy, radiotherapy, transcriptional targeting

This content is open access.

Mots clés
gene therapy, radiotherapy, transcriptional targeting