<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml">The paper presents an application of phosphatidylcholine 45% (PC 45) and polyvinylpyrrolidone (PVP) in formulations of magnesium salts such as Mg(VitB6) and Mg(VitB6Arg) prepared by solid dispersion (SD) techniques. The evaluation of influence of the selected carriers on some physicochemical properties of solid dispersions and on the absorption process of Mg +2 ions in vitro were made. An infrared (IR) spectra study suggested creation of a hydrogen bond between the carriers and the examined magnesium salts. The results of the following thermal analysis: differential thermal analysis (DTA), thermogravimetry (TG), and differential scanning calorimetry (DSC) showed that application of PVP into SD lower the temperature of the decomposition process. However, in the case of PC 45 into SD the characteristic thermal effects of higher temperatures were observed. Moreover, values of the enthalpy SD of decomposition process were decreased. The results of these studies on absorption process of Mg2+ ions in vitro showed the positive influence of the applied carriers on the partition coefficient values (log P) in the examined formulation.</abstract>

The paper presents an application of phosphatidylcholine 45% (PC 45) and polyvinylpyrrolidone (PVP) in formulations of magnesium salts such as Mg(VitB6) and Mg(VitB6Arg) prepared by solid dispersion (SD) techniques. The evaluation of influence of the selected carriers on some physicochemical properties of solid dispersions and on the absorption process of Mg +2 ions in vitro were made. An infrared (IR) spectra study suggested creation of a hydrogen bond between the carriers and the examined magnesium salts. The results of the following thermal analysis: differential thermal analysis (DTA), thermogravimetry (TG), and differential scanning calorimetry (DSC) showed that application of PVP into SD lower the temperature of the decomposition process. However, in the case of PC 45 into SD the characteristic thermal effects of higher temperatures were observed. Moreover, values of the enthalpy SD of decomposition process were decreased. The results of these studies on absorption process of Mg2+ ions in vitro showed the positive influence of the applied carriers on the partition coefficient values (log P) in the examined formulation.

Properties of solid dispersions of selected magnesium salts and the absorption process of Mg2+ ions in vitro

Silesian College of Medicine in Katowice, A. Mickiewicza 29, 40-085 Katowice, Poland

A. Chełkowski Institute of Physics, University of Silesia, Uniwersytecka 4, 40-007 Katowice, Poland

Polish Journal of Medical Physics and Engineering

Properties of solid dispersions of selected magnesium salts and the absorption process of Mg ions in vitro

The paper presents an application of phosphatidylcholine 45% (PC 45) and polyvinylpyrrolidone (PVP) in formulations of magnesium salts such as Mg(VitB6) and...

Properties of solid dispersions of selected magnesium salts and the absorption process of Mg²⁺ ions in vitro

Publié en ligne: 15 févr. 2012

Pages: 55 - 67

DOI: https://doi.org/10.2478/v10013-011-0006-3

Mots clés
Vitamin B6, Arginine, Polyvinylopirrolidone, Phosphatidylcholine, Small intestine

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