<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The objective of the study is to explore the anticancer activity of di-(2-ethylhexyl) phthalate (DEHP) isolated from <italic>Calotropis gigantea </italic>flower against Ehrlich ascites carcinoma cells (EAC) in Swiss albino mice. The activity of DEHP was evaluated at doses of 10, 20 and 40 mg kg<sup>-1</sup> body mass applied intraperitoneally. DEHP showed a significant decrease in viable cell count (<italic>p </italic>&lt; 0.05), mass gain (due to tumour burden) and elevated the life span of EAC cell bearing mice. Altered hematological profiles such as RBC, hemoglobin, WBC and differential count were reverted to normal levels in DEHP-treated mice. DEHP also brought back altered biochemical parameters (glucose, cholesterol, triglycerides, blood urea, SALP and SGOT) to normal level. Results of this study indicate that DEHP show potent dose dependent antitumour activity against EAC <italic>in vivo</italic>.</p></abstract>

The objective of the study is to explore the anticancer activity of di-(2-ethylhexyl) phthalate (DEHP) isolated from Calotropis gigantea flower against Ehrlich ascites carcinoma cells (EAC) in Swiss albino mice. The activity of DEHP was evaluated at doses of 10, 20 and 40 mg kg-1 body mass applied intraperitoneally. DEHP showed a significant decrease in viable cell count (p < 0.05), mass gain (due to tumour burden) and elevated the life span of EAC cell bearing mice. Altered hematological profiles such as RBC, hemoglobin, WBC and differential count were reverted to normal levels in DEHP-treated mice. DEHP also brought back altered biochemical parameters (glucose, cholesterol, triglycerides, blood urea, SALP and SGOT) to normal level. Results of this study indicate that DEHP show potent dose dependent antitumour activity against EAC in vivo.

Antitumour evaluation of di-(2-ethylhexyl) phthalate (DEHP) isolated from Calotropis gigantea L. flower / Evaluacija antitumorskog djelovanja di-(2-etilheksil)-ftalata (DEHP) izoliranog iz cvjetova Calotropis gigantea L.

Department of Biochemistry and Molecular Biology, Faculty of Science, Rajshahi University, Rajshahi-6205, Bangladesh

Acta Pharmaceutica

The objective of the study is to explore the anticancer activity of di-(2-ethylhexyl) phthalate (DEHP) isolated from Calotropis gigantea flower against Ehrlich...

Antitumour evaluation of di-(2-ethylhexyl) phthalate (DEHP) isolated from Calotropis gigantea L. flower / Evaluacija antitumorskog djelovanja di-(2-etilheksil)-ftalata (DEHP) izoliranog iz cvjetova Calotropis gigantea L.

Publié en ligne: 15 janv. 2013

Pages: 607 - 615

DOI: https://doi.org/10.2478/v10007-012-0035-9

Mots clés
Calotropis gigantea (Asclepiadaceae), flower, di-(2-ethylhexyl) phthalate, antitumour activity

This content is open access.

Antitumour evaluation of di-(2-ethylhexyl) phthalate (DEHP) isolated from Calotropis gigantea L. flower / Evaluacija antitumorskog djelovanja di-(2-etilheksil)-ftalata (DEHP) izoliranog iz cvjetova Calotropis gigantea L.

Publié en ligne: 15 janv. 2013

Pages: 607 - 615

DOI: https://doi.org/10.2478/v10007-012-0035-9

Mots clésCalotropis gigantea (Asclepiadaceae), flower, di-(2-ethylhexyl) phthalate, antitumour activity

This content is open access.

Mots clés
Calotropis gigantea (Asclepiadaceae), flower, di-(2-ethylhexyl) phthalate, antitumour activity