<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Spherical crystallization of drugs is the process of obtaining larger particles by agglomeration during crystallization. The most common techniques used to obtain such particles are spherical agglomeration and quasi-emulsion solvent diffusion. Ammonia diffusion systems and crystallo-co-agglomeration are extensions of these techniques. By controlling process parameters during crystallization, such as temperature, stirring rate, type and amount of solvents, or excipient selection, it is possible to control the formation of agglomerates and obtain spherical particles of the desired size, porosity, or hardness. Researchers have reported that the particles produced have improved micromeritic, physical, and mechanical properties, which make them suitable for direct compression. In some cases, when additional excipients are incorporated during spherical crystallization, biopharmaceutical parameters including the bioavailability of drugs can also be tailored.</p></abstract>

Spherical crystallization of drugs is the process of obtaining larger particles by agglomeration during crystallization. The most common techniques used to obtain such particles are spherical agglomeration and quasi-emulsion solvent diffusion. Ammonia diffusion systems and crystallo-co-agglomeration are extensions of these techniques. By controlling process parameters during crystallization, such as temperature, stirring rate, type and amount of solvents, or excipient selection, it is possible to control the formation of agglomerates and obtain spherical particles of the desired size, porosity, or hardness. Researchers have reported that the particles produced have improved micromeritic, physical, and mechanical properties, which make them suitable for direct compression. In some cases, when additional excipients are incorporated during spherical crystallization, biopharmaceutical parameters including the bioavailability of drugs can also be tailored.

Spherical crystallization of drugs

Faculty of Pharmacy, University of Ljubljana, 1000 Ljubljana, Slovenia

Acta Pharmaceutica

{"article-title":"Spherical crystallization of drugs"}

Spherical crystallization of drugs is the process of obtaining larger particles by agglomeration during crystallization. The most common techniques used to...

Spherical crystallization of drugs

Publié en ligne: 03 avr. 2012

Pages: 1 - 14

DOI: https://doi.org/10.2478/v10007-012-0010-5

Mots clés
sferična kristalizacija, aglomeracija, difuzija topila, izboljšane lastnosti delcev

This content is open access.

Spherical crystallization of drugs

Publié en ligne: 03 avr. 2012

Pages: 1 - 14

DOI: https://doi.org/10.2478/v10007-012-0010-5

Mots cléssferična kristalizacija, aglomeracija, difuzija topila, izboljšane lastnosti delcev

This content is open access.

Mots clés
sferična kristalizacija, aglomeracija, difuzija topila, izboljšane lastnosti delcev