<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>The objective of the present investigation was to prepare and evaluate ocular inserts of moxifloxacin. An ocular insert was made from an aqueous dispersion of moxifloxacin, sodium alginate, polyvinyl alcohol, and dibutyl phthalate by the film casting method. The ocular insert (5.5 mm diameter) was cross-linked by CaCl<sub>2</sub> and was coated with Eudragit S-100, RL-100, RS-100, E-100 or L-100. The <italic>in vitro</italic> drug drainage/permeation studies were carried out using an all-glass modified Franz diffusion cell. The drug concentration and mucoadhesion time of the ocular insert were found satisfactory. Cross-linking and coating with polymers extended the drainage from inserts. The cross-linked ocular insert coated with Eudragit RL-100 showed maximum drug permeation compared to other formulations.</p></abstract>

The objective of the present investigation was to prepare and evaluate ocular inserts of moxifloxacin. An ocular insert was made from an aqueous dispersion of moxifloxacin, sodium alginate, polyvinyl alcohol, and dibutyl phthalate by the film casting method. The ocular insert (5.5 mm diameter) was cross-linked by CaCl2 and was coated with Eudragit S-100, RL-100, RS-100, E-100 or L-100. The in vitro drug drainage/permeation studies were carried out using an all-glass modified Franz diffusion cell. The drug concentration and mucoadhesion time of the ocular insert were found satisfactory. Cross-linking and coating with polymers extended the drainage from inserts. The cross-linked ocular insert coated with Eudragit RL-100 showed maximum drug permeation compared to other formulations.

Design and evaluation of moxifloxacin hydrochloride ocular inserts

Chitkara College of Pharmacy, Chandigarh-Patiala National, Chitkara University, Highway, Rajpura, Rajpura-140401, Patiala, Punjab, India

Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research (formerly College of Pharmacy), University of Delhi, Pushp Vihar Sector III, New Delhi-110017, India

Acta Pharmaceutica

{"article-title":"Design and evaluation of moxifloxacin hydrochloride ocular inserts"}

The objective of the present investigation was to prepare and evaluate ocular inserts of moxifloxacin. An ocular insert was made from an aqueous dispersion of...

Design and evaluation of moxifloxacin hydrochloride ocular inserts

Publié en ligne: 03 avr. 2012

Pages: 93 - 104

DOI: https://doi.org/10.2478/v10007-012-0002-5

Mots clés
moksifloksacin, okularni umetak, kornea koze

This content is open access.

Design and evaluation of moxifloxacin hydrochloride ocular inserts

Publié en ligne: 03 avr. 2012

Pages: 93 - 104

DOI: https://doi.org/10.2478/v10007-012-0002-5

Mots clésmoksifloksacin, okularni umetak, kornea koze

This content is open access.

Mots clés
moksifloksacin, okularni umetak, kornea koze