<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Liquid antisolvent process was explored as a solubility modulating tool. Bicalutamide, a poorly water soluble drug, was used as a candidate. Low aqueous solubility and poor dissolution of bicalutamide results into poor and variable bioavailability. Therefore, the objective of the present work was to modify the solubility of bicalutamide using the liquid antisolvent precipitation process. HPMC E5 and Poloxamer 407 were shortlisted as a hydrophilic polymer and surfactant, respectively, for the process. Process optimization was done with respect to the hydrophilic polymer, surfactant and drug loading concentration. The resultant microcrystals were characterized with various instrumental techniques for material characterization such as IR, DSC, SEM, XRD, particle size, specific surface area and dissolution kinetics.</p></abstract>

Liquid antisolvent process was explored as a solubility modulating tool. Bicalutamide, a poorly water soluble drug, was used as a candidate. Low aqueous solubility and poor dissolution of bicalutamide results into poor and variable bioavailability. Therefore, the objective of the present work was to modify the solubility of bicalutamide using the liquid antisolvent precipitation process. HPMC E5 and Poloxamer 407 were shortlisted as a hydrophilic polymer and surfactant, respectively, for the process. Process optimization was done with respect to the hydrophilic polymer, surfactant and drug loading concentration. The resultant microcrystals were characterized with various instrumental techniques for material characterization such as IR, DSC, SEM, XRD, particle size, specific surface area and dissolution kinetics.

Liquid antisolvent precipitation process for solubility modulation of bicalutamide

Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai-400019 India

Acta Pharmaceutica

Liquid antisolvent process was explored as a solubility modulating tool. Bicalutamide, a poorly water soluble drug, was used as a candidate. Low aqueous...

Liquid antisolvent precipitation process for solubility modulation of bicalutamide

Publié en ligne: 25 déc. 2011

Pages: 435 - 445

DOI: https://doi.org/10.2478/v10007-011-0036-0

Mots clés
bikalutamid, povećanje topljivosti, oslobađanje, tekućinska antisolvent precipitacija

This content is open access.

Liquid antisolvent precipitation process for solubility modulation of bicalutamide

Publié en ligne: 25 déc. 2011

Pages: 435 - 445

DOI: https://doi.org/10.2478/v10007-011-0036-0

Mots clésbikalutamid, povećanje topljivosti, oslobađanje, tekućinska antisolvent precipitacija

This content is open access.

Mots clés
bikalutamid, povećanje topljivosti, oslobađanje, tekućinska antisolvent precipitacija