<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Twenty Baylis-Hillman adducts were synthesized from different aromatic aldehydes and activated vinyl derivatives. The adducts, which are differently substituted 3-hydroxy-2-methylene-3-phenylpropionic acid derivatives, were screened for their antimicrobial activity <italic>in vitro</italic> by the serial dilution method. Many of these molecules displayed potent antibacterial and antifungal activities. The ease of synthesis from low-cost starting materials along with potent antimicrobial activity of these molecules provide the lead for further improvement of activity and reflect the possibility of therapeutic use.</p></abstract>

Twenty Baylis-Hillman adducts were synthesized from different aromatic aldehydes and activated vinyl derivatives. The adducts, which are differently substituted 3-hydroxy-2-methylene-3-phenylpropionic acid derivatives, were screened for their antimicrobial activity in vitro by the serial dilution method. Many of these molecules displayed potent antibacterial and antifungal activities. The ease of synthesis from low-cost starting materials along with potent antimicrobial activity of these molecules provide the lead for further improvement of activity and reflect the possibility of therapeutic use.

Antimicrobial potential of 3-hydroxy-2-methylene-3-phenylpropionic acid derivatives

Advanced Research Laboratory in Synthetic and Natural Product Chemistry V. G. Vaze College, Mumbai University, Mulund (E) Mumbai-4000081, India

Acta Pharmaceutica

Twenty Baylis-Hillman adducts were synthesized from different aromatic aldehydes and activated vinyl derivatives. The adducts, which are differently...

Antimicrobial potential of 3-hydroxy-2-methylene-3-phenylpropionic acid derivatives

Publié en ligne: 25 déc. 2011

Pages: 447 - 455

DOI: https://doi.org/10.2478/v10007-011-0034-2

Mots clés
derivati 3-hidroksi-2-metilen-3-fenilpropionske kiseline, antibakterijsko djelovanje, antifungalno djelovanje, Baylis-Hillmanova reakcija

This content is open access.

Antimicrobial potential of 3-hydroxy-2-methylene-3-phenylpropionic acid derivatives

Publié en ligne: 25 déc. 2011

Pages: 447 - 455

DOI: https://doi.org/10.2478/v10007-011-0034-2

Mots clésderivati 3-hidroksi-2-metilen-3-fenilpropionske kiseline, antibakterijsko djelovanje, antifungalno djelovanje, Baylis-Hillmanova reakcija

This content is open access.

Mots clés
derivati 3-hidroksi-2-metilen-3-fenilpropionske kiseline, antibakterijsko djelovanje, antifungalno djelovanje, Baylis-Hillmanova reakcija