<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>The objective of the study was to develop a suitable trans-dermal delivery system for propranolol hydrochloride (PPL) <italic>via</italic> employing chitosan as a film former. Drug concentration uniformity, thickness, moisture uptake capacity and skin bioadhesion of the films were characterized. The effects of chitosan and PPL concentration and different penetration enhancers on the release and permeation profiles from the films were investigated. Skin irritation of the candidate film was evaluated. Chitosan film (PPL 2 mg cm<sup>-2</sup>, chitosan 2 %, <italic>m/m</italic>, cineol 10 %, <italic>m/m</italic>) was found nonirritant and achieved 88.2 % release after 8 hours in phosphate buffer. Significant high (<italic>p</italic> &lt; 0.001) permeation of PPL through rat skin was obtained using this film compared to the film without enhancer (about 8 times enhancement factor), making it a promising trans-dermal delivery system for PPL.</p></abstract>

The objective of the study was to develop a suitable trans-dermal delivery system for propranolol hydrochloride (PPL) via employing chitosan as a film former. Drug concentration uniformity, thickness, moisture uptake capacity and skin bioadhesion of the films were characterized. The effects of chitosan and PPL concentration and different penetration enhancers on the release and permeation profiles from the films were investigated. Skin irritation of the candidate film was evaluated. Chitosan film (PPL 2 mg cm-2, chitosan 2 %, m/m, cineol 10 %, m/m) was found nonirritant and achieved 88.2 % release after 8 hours in phosphate buffer. Significant high (p < 0.001) permeation of PPL through rat skin was obtained using this film compared to the film without enhancer (about 8 times enhancement factor), making it a promising trans-dermal delivery system for PPL.

Design and evaluation of a bioadhesive film for transdermal delivery of propranolol hydrochloride

Department of Pharmaceutics and Pharmacy Practice, Dubai Pharmacy College, Dubai, UAE

Department of Pharmaceutics College of Pharmacy, University of Basra, Basra, Iraq

Department of Pharmaceutics, RAK College of Pharmaceutical Sciences Ras Al-Khaimah Medical and Health Sciences University, Ras Al-Khaimah UAE

College of Pharmacy, University of Baghdad, Baghdad, Iraq

Acta Pharmaceutica

The objective of the study was to develop a suitable trans-dermal delivery system for propranolol hydrochloride (PPL) via employing chitosan as a film former....

Design and evaluation of a bioadhesive film for transdermal delivery of propranolol hydrochloride

Publié en ligne: 26 sept. 2011

Pages: 271 - 282

DOI: https://doi.org/10.2478/v10007-011-0025-3

Mots clés
transdermalna isporuka, propranolol hidroklorid, kitozanski film, sredstvo za povećanje permeacije

This content is open access.

Design and evaluation of a bioadhesive film for transdermal delivery of propranolol hydrochloride

Publié en ligne: 26 sept. 2011

Pages: 271 - 282

DOI: https://doi.org/10.2478/v10007-011-0025-3

Mots cléstransdermalna isporuka, propranolol hidroklorid, kitozanski film, sredstvo za povećanje permeacije

This content is open access.

Mots clés
transdermalna isporuka, propranolol hidroklorid, kitozanski film, sredstvo za povećanje permeacije