<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Experiments were done to assess the compatibility of nateglinide with selected excipients in the development of immediate release tablets of nateglinide by thermal and isothermal stress testing (IST) techniques. To evaluate the drug-excipient compatibility, different techniques such as differential scanning calorimetric (DSC) study, infra-red (IR) spectrophotometric study and isothermal stress testing were adopted. The results of DSC study showed that magnesium stearate exhibited some interaction with nateglinide. However, the results of IR, and IST studies showed that all the excipients used in the formula were compatible with nateglinide. Optimized formulations developed using the compatible excipients were found to be stable over 3 months of accelerated stability studies (40 ± 2°C and 75 ± 5% RH). Overall, compatibility of excipients with nateglinide was successfully evaluated using a combination of thermal and IST methods and the formulations developed using the compatible excipients were found to be stable.</p></abstract>

Experiments were done to assess the compatibility of nateglinide with selected excipients in the development of immediate release tablets of nateglinide by thermal and isothermal stress testing (IST) techniques. To evaluate the drug-excipient compatibility, different techniques such as differential scanning calorimetric (DSC) study, infra-red (IR) spectrophotometric study and isothermal stress testing were adopted. The results of DSC study showed that magnesium stearate exhibited some interaction with nateglinide. However, the results of IR, and IST studies showed that all the excipients used in the formula were compatible with nateglinide. Optimized formulations developed using the compatible excipients were found to be stable over 3 months of accelerated stability studies (40 ± 2°C and 75 ± 5% RH). Overall, compatibility of excipients with nateglinide was successfully evaluated using a combination of thermal and IST methods and the formulations developed using the compatible excipients were found to be stable.

Compatibility studies of nateglinide with excipients in immediate release tablets

Department of Pharmaceutical Technology, Gayatri College of Pharmacy, Sambalpur, Odisha-768200, India

Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh Assam-786004, India

University Department of Pharmaceutical Sciences, Utkal University, Bhubaneswar Orissa, India

Acta Pharmaceutica

Experiments were done to assess the compatibility of nateglinide with selected excipients in the development of immediate release tablets of nateglinide by...

Compatibility studies of nateglinide with excipients in immediate release tablets

Publié en ligne: 17 juin 2011

Pages: 237 - 247

DOI: https://doi.org/10.2478/v10007-011-0016-4

Mots clés
nateglinid, tableta za trenutno oslobađanje, inerakcije lijek-ekscipiens

This content is open access.

Compatibility studies of nateglinide with excipients in immediate release tablets

Publié en ligne: 17 juin 2011

Pages: 237 - 247

DOI: https://doi.org/10.2478/v10007-011-0016-4

Mots clésnateglinid, tableta za trenutno oslobađanje, inerakcije lijek-ekscipiens

This content is open access.

Mots clés
nateglinid, tableta za trenutno oslobađanje, inerakcije lijek-ekscipiens