<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>In the last few years, various studies have been providing evidence that metal ions are critically involved in the pathogenesis of major neurological diseases (Alzheimer, Parkinson). Metal ion chelators have been suggested as potential therapies for diseases involving metal ion imbalance. Neurodegeneration is an excellent target for exploiting the metal chelator approach to therapeutics. In contrast to the direct chelation approach in metal ion overload disorders, in neurodegeneration the goal seems to be a better and subtle modulation of metal ion homeostasis, aimed at restoring ionic balance. Thus, moderate chelators able to coordinate deleterious metals without disturbing metal homeostasis are needed. To date, several chelating agents have been investigated for their potential to treat neurodegeneration, and a series of 8-hydroxyquinoline analogues showed the greatest potential for the treatment of neurodegenerative diseases.</p></abstract>

In the last few years, various studies have been providing evidence that metal ions are critically involved in the pathogenesis of major neurological diseases (Alzheimer, Parkinson). Metal ion chelators have been suggested as potential therapies for diseases involving metal ion imbalance. Neurodegeneration is an excellent target for exploiting the metal chelator approach to therapeutics. In contrast to the direct chelation approach in metal ion overload disorders, in neurodegeneration the goal seems to be a better and subtle modulation of metal ion homeostasis, aimed at restoring ionic balance. Thus, moderate chelators able to coordinate deleterious metals without disturbing metal homeostasis are needed. To date, several chelating agents have been investigated for their potential to treat neurodegeneration, and a series of 8-hydroxyquinoline analogues showed the greatest potential for the treatment of neurodegenerative diseases.

Metal ions, Alzheimer's disease and chelation therapy

Faculty of Pharmacy and Biochemistry, University of Zagreb, 10000 Zagreb, Croatia

Acta Pharmaceutica

{"article-title":"Metal ions, Alzheimer's disease and chelation therapy"}

In the last few years, various studies have been providing evidence that metal ions are critically involved in the pathogenesis of major neurological diseases...

Metal ions, Alzheimer's disease and chelation therapy

Publié en ligne: 15 mars 2011

Pages: 1 - 14

DOI: https://doi.org/10.2478/v10007-011-0006-6

Mots clés
kovinski ioni, Alzheimerova bolest, neurodegeneracija, kovinski kelatori, kelacijska terapija

This content is open access.

Metal ions, Alzheimer's disease and chelation therapy

Publié en ligne: 15 mars 2011

Pages: 1 - 14

DOI: https://doi.org/10.2478/v10007-011-0006-6

Mots cléskovinski ioni, Alzheimerova bolest, neurodegeneracija, kovinski kelatori, kelacijska terapija

This content is open access.

Mots clés
kovinski ioni, Alzheimerova bolest, neurodegeneracija, kovinski kelatori, kelacijska terapija