<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>The aim of the work was to synthesize heterocyclic compounds from 2-aminoprop-1-ene-1,1,3-tricarbonitrile and to study their antitumor activities. The title reagent reacted with cyclohexanone to give the ethylidene derivative <bold>2</bold>. The reactivity of the latter product towards different chemical reagents was studied to give tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives. The newly synthesized products were screened as antitumor agents on the <italic>in vitro</italic> growth of three human tumor cell lines representing different tumor types, namely, breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268). It was found that some of these compounds showed inhibitory effects on the three cell lines, indicating their potential use in the development of oncology products.</p></abstract>

The aim of the work was to synthesize heterocyclic compounds from 2-aminoprop-1-ene-1,1,3-tricarbonitrile and to study their antitumor activities. The title reagent reacted with cyclohexanone to give the ethylidene derivative 2. The reactivity of the latter product towards different chemical reagents was studied to give tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives. The newly synthesized products were screened as antitumor agents on the in vitro growth of three human tumor cell lines representing different tumor types, namely, breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268). It was found that some of these compounds showed inhibitory effects on the three cell lines, indicating their potential use in the development of oncology products.

Use of 2-aminoprop-1-ene-1,1,3-tricarbonitrile for the synthesis of tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives with potential antitumor activities

October University for Modern Sciences and Arts, El Wahaat Road, October City, A.R. Egypt

Chemistry Department, Faculty of Science, Cairo University, Giza, A.R. Egypt

Applied Medical Sciences, Department Community College in Quaryat, Al Jouf University, Al Jouf, Saudi Arabia

Acta Pharmaceutica

The aim of the work was to synthesize heterocyclic compounds from 2-aminoprop-1-ene-1,1,3-tricarbonitrile and to study their antitumor activities. The title...

Use of 2-aminoprop-1-ene-1,1,3-tricarbonitrile for the synthesis of tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives with potential antitumor activities

Publié en ligne: 15 mars 2011

Pages: 51 - 62

DOI: https://doi.org/10.2478/v10007-011-0001-y

Mots clés
tetrahidronaftalen, heksahidrokinolin, heksahidrocinolin, antitumorsko djelovanje

This content is open access.

Use of 2-aminoprop-1-ene-1,1,3-tricarbonitrile for the synthesis of tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives with potential antitumor activities

Publié en ligne: 15 mars 2011

Pages: 51 - 62

DOI: https://doi.org/10.2478/v10007-011-0001-y

Mots cléstetrahidronaftalen, heksahidrokinolin, heksahidrocinolin, antitumorsko djelovanje

This content is open access.

Mots clés
tetrahidronaftalen, heksahidrokinolin, heksahidrocinolin, antitumorsko djelovanje