<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>The purpose of the present study was to design muco-adhesive chitosan microspheres containing amoxicillin. Chitosan microspheres with a small particle size and good sphericity were prepared by a spray-drying method followed by chemical treatment with a chemical crosslinking agent (glutaraldehyde). Parameters affecting the crosslinking extent of the crosslinking time and the concentration of the crosslinker agent. Crosslinked spray-dried chitosan microspheres were analyzed for their morphological aspects, particle size, drug entrapment efficiency, swelling percent and <italic>in vitro</italic> drug release. Batch M4 with a drug polymer ratio of 1:2, dissolved in minimum concentration of acetic acid solution treated with glutraldehyde, was found to be optimal giving controlled drug release for 10 h. It was found that both the increase of glutaraldehyde concentration and crosslinking duration decreased the swelling capacity of chitosan microspheres. This could be directly correlated to drug release from the microspheres.</p></abstract>

The purpose of the present study was to design muco-adhesive chitosan microspheres containing amoxicillin. Chitosan microspheres with a small particle size and good sphericity were prepared by a spray-drying method followed by chemical treatment with a chemical crosslinking agent (glutaraldehyde). Parameters affecting the crosslinking extent of the crosslinking time and the concentration of the crosslinker agent. Crosslinked spray-dried chitosan microspheres were analyzed for their morphological aspects, particle size, drug entrapment efficiency, swelling percent and in vitro drug release. Batch M4 with a drug polymer ratio of 1:2, dissolved in minimum concentration of acetic acid solution treated with glutraldehyde, was found to be optimal giving controlled drug release for 10 h. It was found that both the increase of glutaraldehyde concentration and crosslinking duration decreased the swelling capacity of chitosan microspheres. This could be directly correlated to drug release from the microspheres.

Formulation and <italic>in vitro</italic> characterization of spray dried microspheres of amoxicillin

S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Mehsana-Gozaria Highway Kherva-382711, Gujarat, India

Nootan College of Pharmacy, Gujarat Technical University, Visnagar-384315 Gujarat, India

Kalol Institute of Pharmacy, Gujarat Technical University, B/h Old Janpath Hotel, National Highway, Kalol-382721 Gujarat, India

Acta Pharmaceutica

Formulation and  characterization of spray dried microspheres of amoxicillin

The purpose of the present study was to design muco-adhesive chitosan microspheres containing amoxicillin. Chitosan microspheres with a small particle size and...

Formulation and in vitro characterization of spray dried microspheres of amoxicillin

Publié en ligne: 17 déc. 2010

Pages: 455 - 465

DOI: https://doi.org/10.2478/v10007-010-0034-7

Mots clés
amoksicilin, produljeno oslobađanje, kitozan, mikrosfere dobivene sušenjem sprejom

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