<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>The purpose of the study was to develop an optimized thermoreversible <italic>in situ</italic> gelling ophthalmic drug delivery system based on Pluronic F 127, containing moxifloxacin hydrochloride as a model drug. A 3<sup>2</sup> full factorial design was employed with two polymers: Pluronic F 68 and Gelrite as independent variables used in combination with Pluronic F 127. Gelation temperature, gel strength, bioadhesion force, viscosity and <italic>in vitro</italic> drug release after 1 and 10 h were selected as dependent variables. Pluronic F 68 loading with Pluronic F 127 was found to have a significant effect on gelation temperature of the formulation and to be of importance for gel formation at temperatures 33-36 °C. Gelrite loading showed a positive effect on bioadhesion force and gel strength and was also found helpful in controling the release rate of the drug. The quadratic mathematical model developed is applicable to predicting formulations with desired gelation temperature, gel strength, bioadhesion force and drug release properties.</p></abstract>

The purpose of the study was to develop an optimized thermoreversible in situ gelling ophthalmic drug delivery system based on Pluronic F 127, containing moxifloxacin hydrochloride as a model drug. A 32 full factorial design was employed with two polymers: Pluronic F 68 and Gelrite as independent variables used in combination with Pluronic F 127. Gelation temperature, gel strength, bioadhesion force, viscosity and in vitro drug release after 1 and 10 h were selected as dependent variables. Pluronic F 68 loading with Pluronic F 127 was found to have a significant effect on gelation temperature of the formulation and to be of importance for gel formation at temperatures 33-36 °C. Gelrite loading showed a positive effect on bioadhesion force and gel strength and was also found helpful in controling the release rate of the drug. The quadratic mathematical model developed is applicable to predicting formulations with desired gelation temperature, gel strength, bioadhesion force and drug release properties.

Thermoreversible mucoadhesive ophthalmic <italic>in situ</italic> hydrogel: Design and optimization using a combination of polymers

Department of Pharmaceutics, K. B. Institute of Pharmaceutical Education and Research, Gandhinagar Gujarat-382023, India

Department of Pharmaceutics, Shri Sarvajanik Pharmacy College, Mehsana-384001, India

C. U. Shah College of Pharmacy and Research, Wadhwan, Gujarat-363030 India

Acta Pharmaceutica

Thermoreversible mucoadhesive ophthalmic  hydrogel: Design and optimization using a combination of polymers

The purpose of the study was to develop an optimized thermoreversible in situ gelling ophthalmic drug delivery system based on Pluronic F 127, containing...

Thermoreversible mucoadhesive ophthalmic in situ hydrogel: Design and optimization using a combination of polymers

Publié en ligne: 06 déc. 2010

Pages: 349 - 360

DOI: https://doi.org/10.2478/v10007-010-0029-4

Mots clés
moksifloksacin hidroklorid, geliranje, oftalmička isporuka lijeka, mukoadhezivni polimeri, 3 potpuno faktorijsko dizajniranje

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