<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Mucilage extracted from <italic>Plantago psyllium</italic> seeds was evaluated for inertness and safety parameters. The suitability of psyllium mucilage for a pharmaceutical binder was assessed in paracetamol tablets. Properties of the granules prepared using different concentrations of psyllium mucilage was compared with PVP and tragacanth. Psyllium mucilage at 5 % (<italic>m/m</italic>) was found to be comparable with 3 % (<italic>m/m</italic>) of PVP. Investigated paracetamol tablets indicated that psyllium mucilage can retard the drug release.</p></abstract>

Mucilage extracted from Plantago psyllium seeds was evaluated for inertness and safety parameters. The suitability of psyllium mucilage for a pharmaceutical binder was assessed in paracetamol tablets. Properties of the granules prepared using different concentrations of psyllium mucilage was compared with PVP and tragacanth. Psyllium mucilage at 5 % (m/m) was found to be comparable with 3 % (m/m) of PVP. Investigated paracetamol tablets indicated that psyllium mucilage can retard the drug release.

Evaluation of binding properties of <italic>Plantago psyllium</italic> seed mucilage

Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran

Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Acta Pharmaceutica

Evaluation of binding properties of  seed mucilage

Mucilage extracted from Plantago psyllium seeds was evaluated for inertness and safety parameters. The suitability of psyllium mucilage for a pharmaceutical...

Evaluation of binding properties of Plantago psyllium seed mucilage

Publié en ligne: 06 déc. 2010

Pages: 339 - 348

DOI: https://doi.org/10.2478/v10007-010-0028-5

Mots clés
sluz, paracetamol, vezivo, oslobađanje

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