<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml">Efavirenz (EFV) tablets of different doses were prepared by a wet granulation process using different superdisintegrants such as crosscarmellose sodium (CCS), sodium starch glycollate (SSG) and crosspovidone (CP) to evaluate the role of different disintegrants on the <italic>in vitro</italic> release of EFV. Further, the mode of addition of disintegrants on EFV dissolution from tablets containing 600 mg of the drug was evaluated by incorporating the disintegrants extragranularly (EG), intragranularly (IG) or distributing them equally (IG and EG). <italic>In vitro</italic> dissolution of the prepared tablets was conducted using the recommended medium and a dissolution medium developed in-house, which had the ability to discriminate between the formulations.The <italic>t</italic>50 and <italic>t</italic>80 values were indicative of the fact that the drug release was faster from tablet formulations containing CP. CP was able to release the drug faster than the other two disintegrants in both dissolution media and the drug release was unaffected by the mode of CP addition.</abstract>

Efavirenz (EFV) tablets of different doses were prepared by a wet granulation process using different superdisintegrants such as crosscarmellose sodium (CCS), sodium starch glycollate (SSG) and crosspovidone (CP) to evaluate the role of different disintegrants on the in vitro release of EFV. Further, the mode of addition of disintegrants on EFV dissolution from tablets containing 600 mg of the drug was evaluated by incorporating the disintegrants extragranularly (EG), intragranularly (IG) or distributing them equally (IG and EG). In vitro dissolution of the prepared tablets was conducted using the recommended medium and a dissolution medium developed in-house, which had the ability to discriminate between the formulations.The t50 and t80 values were indicative of the fact that the drug release was faster from tablet formulations containing CP. CP was able to release the drug faster than the other two disintegrants in both dissolution media and the drug release was unaffected by the mode of CP addition.

Impact of superdisintegrants on efavirenz release from tablet formulations

International Specialty Products India Pvt Limited, 6-3-1090/A Bhupal Towers, Rajbhavan Road Somajiguda, Hyderabad-500082 India

Daewoong Pharmaceutical Co., Ltd., Indian Branch Office, C-54/A, Techni Towers, IVth floor, A.P.I.E., Balanagar Hyderabad-500037, India

RA Chem Pharma Limited, Road No 18 IDA, Nacharam, Hyderabad-500076 India

Acta Pharmaceutica

{"article-title":"Impact of superdisintegrants on efavirenz release from tablet formulations"}

Efavirenz (EFV) tablets of different doses were prepared by a wet granulation process using different superdisintegrants such as crosscarmellose sodium (CCS),...

Impact of superdisintegrants on efavirenz release from tablet formulations

Publié en ligne: 06 déc. 2010

Pages: 185 - 195

DOI: https://doi.org/10.2478/v10007-010-0019-6

Mots clés
efavirenc, superdezintegratori, granulacija

This content is open access.

Impact of superdisintegrants on efavirenz release from tablet formulations

Publié en ligne: 06 déc. 2010

Pages: 185 - 195

DOI: https://doi.org/10.2478/v10007-010-0019-6

Mots clésefavirenc, superdezintegratori, granulacija

This content is open access.

Mots clés
efavirenc, superdezintegratori, granulacija