<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>A series of 2-substituted-4,5-diphenyl imidazoles <bold>1a-j</bold> were synthesized by refluxing benzil with different substituted aldehydes in the presence of ammonium acetate and glacial acetic acid. Structures of the synthesized compounds were confirmed on the basis of IR, <sup>1</sup>H NMR and mass spectral data. Compounds <bold>1a-j</bold> were screened for anthelmintic activity. Test results revealed that compounds showed paralysis time of 0.24 to 1.54 min and death time of 0.39 to 4.40 min while the standard drugs albendazole and piperazine citrate showed paralysis time of 0.54 and 0.58 min and death time of 2.16 and 2.47 min, respectively, at the same concentration of 1% (<italic>m/V</italic>). Five compounds, 2-[2-hydroxyphenyl]-4,5-diphenyl imidazole (<bold>1b</bold>), 2-[3-methoxyphenyl]-4,5-diphenyl imidazole (<bold>1c</bold>), 2-[2-phenylethenyl]-4,5-diphenyl imidazole (<bold>1e</bold>), 2-[4-fluorophenyl]-4,5-diphenyl imidazole (<bold>1g</bold>) and 2-[3-nitrophenyl]-4,5-diphenyl imidazole (<bold>1h</bold>) showed significant anthelmintic activity compared to the standard drugs.</p></abstract>

A series of 2-substituted-4,5-diphenyl imidazoles 1a-j were synthesized by refluxing benzil with different substituted aldehydes in the presence of ammonium acetate and glacial acetic acid. Structures of the synthesized compounds were confirmed on the basis of IR, 1H NMR and mass spectral data. Compounds 1a-j were screened for anthelmintic activity. Test results revealed that compounds showed paralysis time of 0.24 to 1.54 min and death time of 0.39 to 4.40 min while the standard drugs albendazole and piperazine citrate showed paralysis time of 0.54 and 0.58 min and death time of 2.16 and 2.47 min, respectively, at the same concentration of 1% (m/V). Five compounds, 2-[2-hydroxyphenyl]-4,5-diphenyl imidazole (1b), 2-[3-methoxyphenyl]-4,5-diphenyl imidazole (1c), 2-[2-phenylethenyl]-4,5-diphenyl imidazole (1e), 2-[4-fluorophenyl]-4,5-diphenyl imidazole (1g) and 2-[3-nitrophenyl]-4,5-diphenyl imidazole (1h) showed significant anthelmintic activity compared to the standard drugs.

Synthesis and anthelmintic activity of some novel 2-substituted-4,5-diphenyl imidazoles

Department of Pharmacy, IIMT College of Medical Sciences, ‘O’Pocket, Ganga Nagar, Mawana Road, Meerut-250001 Uttar Pradesh, India

Acta Pharmaceutica

A series of 2-substituted-4,5-diphenyl imidazoles 1a-j were synthesized by refluxing benzil with different substituted aldehydes in the presence of ammonium...

Synthesis and anthelmintic activity of some novel 2-substituted-4,5-diphenyl imidazoles

Publié en ligne: 06 déc. 2010

Pages: 229 - 235

DOI: https://doi.org/10.2478/v10007-010-0011-1

Mots clés
2-supstituirani-4, 5-difenil imidazoli, anthelmintik, antiparazitik

This content is open access.

Synthesis and anthelmintic activity of some novel 2-substituted-4,5-diphenyl imidazoles

Publié en ligne: 06 déc. 2010

Pages: 229 - 235

DOI: https://doi.org/10.2478/v10007-010-0011-1

Mots clés2-supstituirani-4, 5-difenil imidazoli, anthelmintik, antiparazitik

This content is open access.

Mots clés
2-supstituirani-4, 5-difenil imidazoli, anthelmintik, antiparazitik