Synthesis, anticancer and cytostatic activity of some 6H-indolo[2,3-b]quinoxalines

D. J. Brown (Ed.), Quinoxalines, Wiley, New York 2004.10.1002/0471533408Search in Google Scholar

G. W. H. Cheeseman and R. F. Cookson (Eds.), Condensed Pyrazines, Wiley, New York 1979.Search in Google Scholar

A. Carta, P. Corona and M. Loriga, Quinoxaline 1,4-dioxide: A versatile scaffold end-owed with manifold activities, Curr. Med. Chem. 12 (2005) 2259-2272; DOI: 10.2174/0929867054864831.10.2174/092986705486483116178784Search in Google Scholar

J. Harrmenberg, B. Wahren, J. Bergman, S. Akerfeldt and L. Lundbland, Antiherpes virus activity and mechanism of action of indolo[2,3-b]-quinoxaline and analogs, Antimicrob. Agents Chemother. 32 (1988) 1720-1724.10.1128/AAC.32.11.17201759572855298Search in Google Scholar

J. O. E. Bergman and S. G. Aakerfeldt, Indoloquinoxalines with Substitutients in 6-Position Containing Cyclic Groups, Eur. Pat. 0, 231, 159, 18 Sep 1987; ref. Chem. Abstr. 108 (1988) 6048s.Search in Google Scholar

N. Patel, J. Bergman and A. Graslund, Interaction of the deoxy-oligonucleotide duplex d(CGCGATCGCG)₂ and anti-hepres virus active indolo[2,3-b]-quinoxaline derivatives, Nucleos. Nucleot. Nucl. 10 (1991) 699-700; DOI: 10.1080/07328319108046576.10.1080/07328319108046576Search in Google Scholar

B. Zarranz, A. Jaso, I. Aldana, A. Monge, S. Maurel, E. Deharo, V. Jullian and M. Sauvain, Synthesis and antimalarial activity of new 3-arylquinoxaline-2-carbonitrile derivatives, Arzneim. Forsch. 55 (2005) 754-761.Search in Google Scholar

G. Moarbess, C. Deleuze-Masquefa, V. Bonnard, S. Gayraud-Paniagua, J. Vidal, F. Bressolle, F. Pinguet and B. Pierre-Antoine, In vitro and in vivo anti-tumoral activities of imidazo[1,2-a]quinoxaline, imidazo[1,5-a]quinoxaline, and pyrazolo[1,5-a]quinoxaline derivatives, Bioorg. Med. Chem. 16 (2008) 6601-6610; DOI:10.1016/j.bmc.2008.05.022.10.1016/j.bmc.2008.05.02218513976Search in Google Scholar

K. Toshima, T. Ozawa, T. Kimura and S. Matsumura, The significant effect of the carbohydrate structures on the DNA photocleavage of the quinoxaline-carbohydrate hybrids, Bioorg. Med. Chem. Lett. 14 (2004) 2777-2779; DOI: 10.1016/j.bmcl.2004.03.065.10.1016/j.bmcl.2004.03.06515125931Search in Google Scholar

G. A. Carter, T. Clark, C. S. James and R. S. T. Loeffler, Fungicidal activities of substituted quinoxalines, Pestic. Sci. 14 (1983) 135-144; DOI: 10.1002/ps.2780140207.10.1002/ps.2780140207Search in Google Scholar

P. Sanna, A. Carta, M. Loriga, S. Zanetti and L. Sechi, Preparation and biological evaluation of 6/7-trifluoromethyl(nitro)-, 6,7-difluoro-3-alkyl (aryl)-substituted-quinoxalin-2-ones, Farmaco 54 (1999) 169-177; DOI: 10.1016/S0014-827X (99)00011-7.Search in Google Scholar

J. P. Dirlam, J. E. Presslitz and B. J. Williams, Synthesis and antibacterial activity of some 3(alkylthio) methyl]quinoxaline-1-oxide derivatives, J. Med. Chem. 26 (1983) 1122-1126; DOI: 10.1021/jm00362a007.10.1021/jm00362a0076876079Search in Google Scholar

C. S. Marvel and G. S. Hiers, Isatin, in Organic Syntheses Collection (Ed. A. H. Blatt), 2nd ed., Vol 1, Wiley, New York 1941, pp. 327-330.Search in Google Scholar

J. Azizian, F. B. Shaidaei and H. Kefayati, A facile one-pot method for the preparation of N-alkyl isatins under microwave irradiation, Synth. Commun. 33 (2003) 789-793; DOI: 10.1081/SCC-120016324.10.1081/SCC-120016324Search in Google Scholar

A. Monks, D. Scudiero, P. Skehen, R. Shoemaker, K. Paull, D. Vistica, C. Hose, J. Langley, P. Cronise and A. Vaigro-Wolff, Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines, J. Natl. Cancer Inst. 83 (1991) 757-766; DOI: 10.1093/jnci/83.11.757.10.1093/jnci/83.11.7572041050Search in Google Scholar

P. G. Baraldi, M. Del Carmen Nunez, M. A. Tabrizi, E. De Clercq, J. Balzarini, J. Bermejo, F. Este'vez and R. Romagnoli, Design, synthesis and biological evaluation of hybrid molecules containing α-methylene-γ-butyrolactones and polypyrrole minor groove binders, J. Med. Chem. 47 (2004) 2877-2886; DOI: 10.1021/jm031104y.10.1021/jm031104y15139766Search in Google Scholar

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