<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml">Sterodin® is a novel non-specific immunostimulating drug produced by a combination of bile lipids and bacterial metabolites. In the present study, we investigated some of its (<italic>i</italic>) toxicological and (<italic>ii</italic>) pharmacological properties <italic>in vivo</italic>, and (<italic>iii</italic>) drug-lipid interaction (lipid peroxidation) <italic>in vitro</italic>. We also evaluated the possible (<italic>iv</italic>) Sterodin®-induced lipid peroxidation as well as the effect of ascorbic acid on this peroxidation. We found <italic>LD</italic>50 of Sterodin® to be 31.50 mL kg-1 body mass. In male albino mice, Sterodin® increased the total white blood cells and neutrophils count by 59 and 26%, respectively, on the 6th day, compared to day 0 after injection and stimulated phagocytic activity <italic>in vivo</italic>. We used goat liver as lipid source in drug-lipid interaction studies <italic>in vitro</italic>. Our experiments show that Sterodin® induces lipid peroxidation, which was prevented by ascorbic acid.</abstract>

Sterodin® is a novel non-specific immunostimulating drug produced by a combination of bile lipids and bacterial metabolites. In the present study, we investigated some of its (i) toxicological and (ii) pharmacological properties in vivo, and (iii) drug-lipid interaction (lipid peroxidation) in vitro. We also evaluated the possible (iv) Sterodin®-induced lipid peroxidation as well as the effect of ascorbic acid on this peroxidation. We found LD50 of Sterodin® to be 31.50 mL kg-1 body mass. In male albino mice, Sterodin® increased the total white blood cells and neutrophils count by 59 and 26%, respectively, on the 6th day, compared to day 0 after injection and stimulated phagocytic activity in vivo. We used goat liver as lipid source in drug-lipid interaction studies in vitro. Our experiments show that Sterodin® induces lipid peroxidation, which was prevented by ascorbic acid.

Sterodin®, a novel immunostimulating drug: Some toxicological and pharmacological evaluations <italic>in vivo</italic>, and drug-lipid interaction studies <italic>in vitro</italic>

Dr. B C Roy College of Pharmacy & Allied Health Sciences, Bidhannagar, Durgapur-713206, India

Division of Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700032, India

Acta Pharmaceutica

Sterodin®, a novel immunostimulating drug: Some toxicological and pharmacological evaluations , and drug-lipid interaction studies 

Sterodin® is a novel non-specific immunostimulating drug produced by a combination of bile lipids and bacterial metabolites. In the present study, we...

Sterodin®, a novel immunostimulating drug: Some toxicological and pharmacological evaluations in vivo, and drug-lipid interaction studies in vitro

Publié en ligne: 09 oct. 2009

Pages: 325 - 334

DOI: https://doi.org/10.2478/v10007-009-0030-y

Mots clés
Sterodin®, imunostimulator, askorbinska kiselina, peroksidacija lipida, malondialdehid, reducirani glutation

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