<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>In the present work, a gastroretentive <italic>in situ</italic> gelling liquid formulation for controlled delivery of ranitidine was formulated using sodium alginate (low, medium and high viscosity grades), calcium carbonate (source of cations) and ranitidine. Prepared formulations were evaluated for viscosity, buoyancy lag time and buoyancy duration, drug content and <italic>in vitro</italic> drug release. Formulation variables such as concentration of sodium alginate, calcium carbonate and drug significantly affected the formulation viscosity, floating behavior and <italic>in vitro</italic> drug release. Analysis of the release pattern showed that the drug release from <italic>in situ</italic> gel followed a diffusion mechanism.</p></abstract>

In the present work, a gastroretentive in situ gelling liquid formulation for controlled delivery of ranitidine was formulated using sodium alginate (low, medium and high viscosity grades), calcium carbonate (source of cations) and ranitidine. Prepared formulations were evaluated for viscosity, buoyancy lag time and buoyancy duration, drug content and in vitro drug release. Formulation variables such as concentration of sodium alginate, calcium carbonate and drug significantly affected the formulation viscosity, floating behavior and in vitro drug release. Analysis of the release pattern showed that the drug release from in situ gel followed a diffusion mechanism.

Floating drug delivery of a locally acting H<sub>2</sub>-antagonist: An approach using an <italic>in situ</italic> gelling liquid formulation

Department of Pharmaceutics, National College of Pharmacy, Shimoga-577201, India

Acta Pharmaceutica

Floating drug delivery of a locally acting H-antagonist: An approach using an  gelling liquid formulation

In the present work, a gastroretentive in situ gelling liquid formulation for controlled delivery of ranitidine was formulated using sodium alginate (low,...

Floating drug delivery of a locally acting H₂-antagonist: An approach using an in situ gelling liquid formulation

Publié en ligne: 09 oct. 2009

Pages: 345 - 354

DOI: https://doi.org/10.2478/v10007-009-0021-z

Mots clés
gastroretencija, geliranje, natrijev alginat, ranitidin

This content is open access.

Floating drug delivery of a locally acting H2-antagonist: An approach using an in situ gelling liquid formulation