<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>The purpose of the study was to evaluate the suitability of laboratory scale spheronizer for the production of spherical pellets loaded with diltiazem hydrochloride by wax combination. The 1:1 combination of cetyl alcohol and hydrogenated castor oil, as low and high melting point waxes, were used. The various production variables affecting the different characteristics of pellets and the process efficiency were evaluated. Drug loaded pellets were evaluated for drug release in distilled water. Bowl temperature primarily affects the sphericity and adhesion of pellets to the bowl. Mass temperature has a pronounced effect on size, size distribution and sphericity of pellets. Wax concentration affects all characteristics of pellets but adhesion was least affected. The effect of these three variables can be compensated by optimizing the friction plate speed. It has been found that the highest yield of pellets (850--1400 μm) with maximum sphericity can be produced by using 45 °C bowl temperature, 52 °C mass temperature and 1400 rpm friction plate speed.</p></abstract>

The purpose of the study was to evaluate the suitability of laboratory scale spheronizer for the production of spherical pellets loaded with diltiazem hydrochloride by wax combination. The 1:1 combination of cetyl alcohol and hydrogenated castor oil, as low and high melting point waxes, were used. The various production variables affecting the different characteristics of pellets and the process efficiency were evaluated. Drug loaded pellets were evaluated for drug release in distilled water. Bowl temperature primarily affects the sphericity and adhesion of pellets to the bowl. Mass temperature has a pronounced effect on size, size distribution and sphericity of pellets. Wax concentration affects all characteristics of pellets but adhesion was least affected. The effect of these three variables can be compensated by optimizing the friction plate speed. It has been found that the highest yield of pellets (850--1400 μm) with maximum sphericity can be produced by using 45 °C bowl temperature, 52 °C mass temperature and 1400 rpm friction plate speed.

Production variables affecting characteristics of pellets in melt pelletization with wax combination in a laboratory scale spheronizer

Royal College of Pharmacy and Health Sciences, Andhapasarsa Road Berhampur-760002 Orissa, India

Department of Pharmaceutical Sciences Rashtrasant Tukadoji Maharaj, Nagpur University Campus, Nagpur-440033 (M.S.), India

Acta Pharmaceutica

The purpose of the study was to evaluate the suitability of laboratory scale spheronizer for the production of spherical pellets loaded with diltiazem...

Production variables affecting characteristics of pellets in melt pelletization with wax combination in a laboratory scale spheronizer

Publié en ligne: 29 juin 2009

Pages: 199 - 210

DOI: https://doi.org/10.2478/v10007-009-0013-z

Mots clés
pelete, sferonizator, temperatura peletiranja, cetilni alkohol, hidrogenirano ricinusovo ulje, diltiazem hidroklorid

This content is open access.

Production variables affecting characteristics of pellets in melt pelletization with wax combination in a laboratory scale spheronizer

Publié en ligne: 29 juin 2009

Pages: 199 - 210

DOI: https://doi.org/10.2478/v10007-009-0013-z

Mots cléspelete, sferonizator, temperatura peletiranja, cetilni alkohol, hidrogenirano ricinusovo ulje, diltiazem hidroklorid

This content is open access.

Mots clés
pelete, sferonizator, temperatura peletiranja, cetilni alkohol, hidrogenirano ricinusovo ulje, diltiazem hidroklorid