<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Ternary complexes of meloxicam (ME) (a poorly water soluble anti-inflammatory drug) with hydroxypropyl-β-cyclodextrin (HPβCD) and either a hydrophilic polymer, namely, polyvinyl pyrrolidone (PVP) or a basic amino acid such as L-arginine, were prepared by the spray-drying technique. The solubilizing efficiency, physical properties and dissolution behaviour of each ternary system of ME-HPβCD with either PVP or L-arginine were compared with those of the corresponding binary system of ME-HPβCD. Tablets compressed from the ternary system of ME-HPβCD-L-arginine were compared with plain and commercial tablets. Phase solubility experiments suggested the formation of an inclusion complex of A<sub>L</sub> type. Ternary system of ME-HPβCD-L-arginine exhibited a stability constant 30.3 times higher than the binary system of ME-HPβCD, while the ternary system of ME-HPβCD-PVP increased the stability constant 2.2 times only. The prepared complexes were characterized by scanning electron microscopy, differential scanning calorimetry and infra red spectroscopy. Ternary solid complexes indicated the presence of strong interactions between the components. The dissolution behaviour of ME from different ternary complexes was higher than its dissolution from the binary system. Tablets compressed from ternary complexes of ME-HPβCD-L-arginine highly improved drug release compared to plain and commercial tablets.</p></abstract>

Ternary complexes of meloxicam (ME) (a poorly water soluble anti-inflammatory drug) with hydroxypropyl-β-cyclodextrin (HPβCD) and either a hydrophilic polymer, namely, polyvinyl pyrrolidone (PVP) or a basic amino acid such as L-arginine, were prepared by the spray-drying technique. The solubilizing efficiency, physical properties and dissolution behaviour of each ternary system of ME-HPβCD with either PVP or L-arginine were compared with those of the corresponding binary system of ME-HPβCD. Tablets compressed from the ternary system of ME-HPβCD-L-arginine were compared with plain and commercial tablets. Phase solubility experiments suggested the formation of an inclusion complex of AL type. Ternary system of ME-HPβCD-L-arginine exhibited a stability constant 30.3 times higher than the binary system of ME-HPβCD, while the ternary system of ME-HPβCD-PVP increased the stability constant 2.2 times only. The prepared complexes were characterized by scanning electron microscopy, differential scanning calorimetry and infra red spectroscopy. Ternary solid complexes indicated the presence of strong interactions between the components. The dissolution behaviour of ME from different ternary complexes was higher than its dissolution from the binary system. Tablets compressed from ternary complexes of ME-HPβCD-L-arginine highly improved drug release compared to plain and commercial tablets.

Characterization of ternary complexes of meloxicam-HPβCD and PVP or L-arginine prepared by the spray-drying technique

Department of Industrial Pharmacy, University of Alexandria

Amriya Pharmaceutical Industry, Alexandria, Egypt

Acta Pharmaceutica

Ternary complexes of meloxicam (ME) (a poorly water soluble anti-inflammatory drug) with hydroxypropyl-β-cyclodextrin (HPβCD) and either a hydrophilic polymer,...

Characterization of ternary complexes of meloxicam-HPβCD and PVP or L-arginine prepared by the spray-drying technique

Publié en ligne: 22 déc. 2008

Pages: 455 - 466

DOI: https://doi.org/10.2478/v10007-008-0029-9

Mots clés
meloksikam, hidroksipropil-β-ciklodekstrin, polivinil pirolidon, L-arginin, metoda sušenja sprejom

This content is open access.

Characterization of ternary complexes of meloxicam-HPβCD and PVP or L-arginine prepared by the spray-drying technique

Publié en ligne: 22 déc. 2008

Pages: 455 - 466

DOI: https://doi.org/10.2478/v10007-008-0029-9

Mots clésmeloksikam, hidroksipropil-β-ciklodekstrin, polivinil pirolidon, L-arginin, metoda sušenja sprejom

This content is open access.

Mots clés
meloksikam, hidroksipropil-β-ciklodekstrin, polivinil pirolidon, L-arginin, metoda sušenja sprejom