<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>An acid buffering bioadhesive vaginal (ABBV) gel was developed for the treatment of mixed vaginal infections. Different bioadhesive polymers were evaluated on the basis of their bioadhesive strength, stability and drug release properties. Bioadhesion and release studies showed that guar gum, xanthan gum and hydroxypropyl methylcelullose K4M formed a good combination of bioadhesive polymers to develop the ABBV gel. Monosodium citrate was used as an acid buffering agent to provide acidic pH (4.4). The drugs clotrimazole (antifungal) and metronidazole (antiprotozoal as well as antibacterial) were used in the formulation along with <italic>Lactobacillus</italic> spores to treat mixed vaginal infections. The <italic>ex vivo</italic> retention study showed that the bioadhesive polymers hold the gel for 12-13 hours inside the vaginal tube. Results of the <italic>in vitro</italic> antimicrobial study indicated that the ABBV gel had better antimicrobial action than the commercial intravaginal drug delivery systems and retention was prolonged in an <italic>ex vivo</italic> retention experiment.</p></abstract>

An acid buffering bioadhesive vaginal (ABBV) gel was developed for the treatment of mixed vaginal infections. Different bioadhesive polymers were evaluated on the basis of their bioadhesive strength, stability and drug release properties. Bioadhesion and release studies showed that guar gum, xanthan gum and hydroxypropyl methylcelullose K4M formed a good combination of bioadhesive polymers to develop the ABBV gel. Monosodium citrate was used as an acid buffering agent to provide acidic pH (4.4). The drugs clotrimazole (antifungal) and metronidazole (antiprotozoal as well as antibacterial) were used in the formulation along with Lactobacillus spores to treat mixed vaginal infections. The ex vivo retention study showed that the bioadhesive polymers hold the gel for 12-13 hours inside the vaginal tube. Results of the in vitro antimicrobial study indicated that the ABBV gel had better antimicrobial action than the commercial intravaginal drug delivery systems and retention was prolonged in an ex vivo retention experiment.

Development and <italic>in vitro</italic> evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections

Department of Pharmaceutics, Hamdard University, New Delhi-110062, India

Acta Pharmaceutica

Development and  evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections

An acid buffering bioadhesive vaginal (ABBV) gel was developed for the treatment of mixed vaginal infections. Different bioadhesive polymers were evaluated on...

Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections

Publié en ligne: 22 déc. 2008

Pages: 407 - 419

DOI: https://doi.org/10.2478/v10007-008-0023-2

Mots clés
puferirani gel, vaginalna bioadhezija, bioadhezivni polimeri, miješane vaginalne infekcije

This content is open access.