3D-QSAR studies for the binding affinity toward (R, S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)-propionic acid receptor

H. Bräuner-Osborne, J. Egebjerg, E. Ø. Nielsen, U. Madsen and P. Krogsgaard-Larsen, Ligands for glutamate receptor: Design and therapeutic prospects, J. Med. Chem. 43 (2000) 2609-2645; DOI: 10.1021/jm000007r.10.1021/jm000007rSearch in Google Scholar

R. Dingledine, K. Borges, D. Bowie and S. F. Traynelis, The glutamate receptor ion channels, Pharmacol. Rev. 51 (1999) 7-61.Search in Google Scholar

M. Hollmann and S. Heinemann, Cloned glutamate receptors, Annu. Rev. Neurosci. 17 (1994) 103-108.Search in Google Scholar

G. J. Lees, Pharmacology of AMPA/kainate receptor ligands and their therapeutic potential in neurological and psychiatric disorders, Drugs 59 (2000) 33-78; DOI: 10.2165/00003495-200059010-00004.10.2165/00003495-200059010-00004Search in Google Scholar

U. Madsen, T. B. Stensbøl and P. Krogsgaard-Larsen, Inhibitors of AMPA and kainate receptors, Curr. Med. Chem. 8 (2001) 1291-1301.10.2174/0929867013372210Search in Google Scholar

S. S. Nikam and B. E. Kornberg, AMPA receptor antagonists, Curr. Med. Chem. 8 (2001) 155-170.10.2174/0929867013373877Search in Google Scholar

T. B. Stensbøl, U. Madsen and P. Krogsgaard-Larsen, The AMPA receptor binding site: Focus on agonists and competitive antagonists, Curr. Pharm. Des. 8 (2002) 857-872; DOI: 10.2174/1381612024607090.10.2174/1381612024607090Search in Google Scholar

Y. P. Auberson, Competitive AMPA antagonism: A novel mechanism for antiepileptic drugs, Drugs Fut. 26 (2001) 463-471; DOI: 10.1358/dof.2001.026. 05.659545.Search in Google Scholar

S. D. Donevan and M. Rogawski, GYKI 52466, a 2,3-benzodiazepine, is a highly selective, non-competitive antagonist of AMPA/kainate receptor responses, Neuron 10 (1993) 51-59; DOI: 10.1016/0896-6273(93)90241-I.10.1016/0896-6273(93)90241-ISearch in Google Scholar

A. Tortorella, T. Halonen, N. Sahibzada and K. Gale, A crucial role of the α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid subtype of glutamate receptors in piriform and perirhinal cortex for the initiation and propagation of limbic motor seizures, J. Pharmacol. Exp. Ther. 280 (1997) 1401-1405.Search in Google Scholar

W. Löscher, Pharmacology of glutamate receptor antagonists in the kindling model of epilepsy, Prog. Neurobiol. 54 (1998) 721-741; DOI: 10.1016/S0301-0082(97)00092-0.10.1016/S0301-0082(97)00092-0Search in Google Scholar

W. Loscher, H. Lehmann, B. Behl, D. Seemann, H. J. Teschendorf, H. P. Hofmann, W. Lubisch, T. Hoger, H. G. Lemaire and G. Gross, A new pyrrolyl-quinoxalinedione series of non-NMDA glutamate receptor antagonists: pharmacological characterization and comparison with NBQX and valproate in the kindling model of epilepsy, Eur. J. Neurosci. 11 (1999) 250-262; DOI: 10.1046/j.1460-9568.1999.00432.x.10.1046/j.1460-9568.1999.00432.x9987029Search in Google Scholar

G. R. Desraju, B. Gopalakrishnan, R. K. Jetti, A. Nagarjun, D. Raveendra, J. A. Sarma, M. E. Sobhia and R. Thiagavathi, Computer-aided design of selective cox-2 inhibitors: comparative molecular field analysis, comparative molecular similarity indices analysis, and docking studies of some 1,2-diarylimidazole derivatives, J. Med. Chem. 45 (2002); DOI: 10.1021/jm020198t.10.1021/jm020198t12383010Search in Google Scholar

M. T. Bohm. J. Sturzebecher and G. Klebe, Three dimensional quantitative structure activity relationship analysis using comparative molecular field analysis and comparative molecular similarity search analysis to elucidate selectivity differences of inhibitor binding to trypsin, thrombin and factor Xa, J. Med. Chem. 42 (1999) 458-477; DOI: 10.1021/jm981062r.10.1021/jm981062r9986717Search in Google Scholar

D. Catarzi, V. Colotta, F. Varano, L. Cecchi, G. Filacchioni, A. Galli, C. Costagli and V. Carla, 7-Chloro-4,5-dihydro-8-(1,2,4-triazole-4-yl)-4-oxo-1,2,4-triazolo[1,5-a] quinoxaline-2-carboxylates as novel highly selective AMPA receptor antagonists, J. Med. Chem. 43 (2000) 3824-3826; DOI: 10.1021/jm0009686.10.1021/jm0009686Search in Google Scholar

D. Catarzi, V. Colotta, F. Varano, L. Cecchi, G. Filacchioni, V. R. Calabri, A. Galli, C. Costagli and V. Carla, Synthesis and biological evaluation of analogues of 7-chloro-4,5-dihydro-4-oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5-a] quinox -aline-2-carboxylic acid (TQX-173) as novel selective AMPA receptor antagonists, J. Med. Chem. 47 (2004) 262-272; DOI: 10.1021/jm030906q.10.1021/jm030906qSearch in Google Scholar

D. Catarzi, V. Colotta, F. Varano, L. Cecchi, G. Filacchioni, A. Galli, C. Costagli and V. Carla, Synthesis, ionotropic glutamate receptor binding affinity, and structure-activity relationships of a new set of 4,5-dihydro-8-heteroaryl-4-oxo-1,2,4-triazolo[1,5-a] quinoxaline-2-carboxylates analogues of TQX-173, J. Med. Chem. 44 (2001) 3157-3165; DOI: 10.1021/jm010862q.10.1021/jm010862qSearch in Google Scholar

F. Varano, D. Catarzi, V. Colotta, G. Filacchioni, A. Galli, C. Costagli and V. Carla, Synthesis and biological evaluation of a new set of pyrazolo[1,5-c]quinazoline-2-carboxylates as novel excitatory amino acid antagonists, J. Med. Chem. 45 (2002) 1035-1044; DOI: 10.1021/jm010995b.10.1021/jm010995bSearch in Google Scholar

Y. C. Cheng and W. H. Prusoff, Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50% inhibition (IC₅₀) of an enzymatic reaction, Biochem. Pharmacol. 22 (1973) 3099-3108; DOI: 10.1016/0006-2952(73)90196-2.10.1016/0006-2952(73)90196-2Search in Google Scholar