<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml">The aim of this study was to investigate the activity of <italic>N</italic>-phthaloyl-glycine-hydroxamic acid (Phth-Gly-HA) as a new iron chelator <italic>in vivo</italic> to be used in iron overload diseases. After intraperitoneal application of Phth-Gly-HA to male rats (1 mg kg-1 body mass) once a day for seven days, iron serum level decreased by 21%, whereas the iron value dropped by 32% in female rats (1.5 mg kg-1 body mass). The results indicate that the tested substance has the ability to bind serum iron by complexation. Besides transferrin iron release, mobilization of ferritin iron is also possible.</abstract>

The aim of this study was to investigate the activity of N-phthaloyl-glycine-hydroxamic acid (Phth-Gly-HA) as a new iron chelator in vivo to be used in iron overload diseases. After intraperitoneal application of Phth-Gly-HA to male rats (1 mg kg-1 body mass) once a day for seven days, iron serum level decreased by 21%, whereas the iron value dropped by 32% in female rats (1.5 mg kg-1 body mass). The results indicate that the tested substance has the ability to bind serum iron by complexation. Besides transferrin iron release, mobilization of ferritin iron is also possible.

<italic>N</italic>-Phthaloyl-glycine-hydroxamic acid as serum iron chelator in rats

Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia

Clinical Laboratory, General Hospital Pula, Pula, Croatia

Agency for Medicinal Products and Medicinal Devices of the Republic of Croatia, Zagreb, Croatia

Acta Pharmaceutica

-Phthaloyl-glycine-hydroxamic acid as serum iron chelator in rats

The aim of this study was to investigate the activity of N-phthaloyl-glycine-hydroxamic acid (Phth-Gly-HA) as a new iron chelator in vivo to be used in iron...

N-Phthaloyl-glycine-hydroxamic acid as serum iron chelator in rats

Publié en ligne: 30 mai 2008

Pages: 231 - 236

DOI: https://doi.org/10.2478/v10007-008-0010-7

Mots clés
-ftaloil-glicin-hidroksamska kiselina, kelatori željeza, bolesti uzrokovane viškom željeza

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