<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>In continuation of our search for new substituted pyridine based anti-inflammatories, reaction of 1-(2-thienyl or furanyl)-3-(2-hydroxyphenyl)-2-propen-1-ones (1) with malononitrile in alcoholic KOH solution afforded a mixture of 4-alkoxy-2-(2-thienyl or furanyl)-5<italic>H</italic>-[1]benzopyrano[3,4-c]pyridine-5-ones (2) and 2-alkoxy-4-amino-6- (2-thienyl or furanyl)-3,5-pyridinedicarbonitriles (3). Some of the synthesized compounds were evaluated for their anti-inflammatory and analgesic activities compared to diclofenac potassium as positive control. Detailed synthesis, spectroscopic and toxicity data are reported.</p></abstract>

In continuation of our search for new substituted pyridine based anti-inflammatories, reaction of 1-(2-thienyl or furanyl)-3-(2-hydroxyphenyl)-2-propen-1-ones (1) with malononitrile in alcoholic KOH solution afforded a mixture of 4-alkoxy-2-(2-thienyl or furanyl)-5H-[1]benzopyrano[3,4-c]pyridine-5-ones (2) and 2-alkoxy-4-amino-6- (2-thienyl or furanyl)-3,5-pyridinedicarbonitriles (3). Some of the synthesized compounds were evaluated for their anti-inflammatory and analgesic activities compared to diclofenac potassium as positive control. Detailed synthesis, spectroscopic and toxicity data are reported.

Anti-inflammatory and analgesic activities of some newly synthesized pyridinedicarbonitrile and benzopyranopyridine derivatives

Pesticide Chemistry Department, National Research Centre Doki, Cairo, Egypt

Research Units, Hi-Care Pharmaceutical Co., Cairo, Egypt

Acta Pharmaceutica

In continuation of our search for new substituted pyridine based anti-inflammatories, reaction of 1-(2-thienyl or furanyl)-3-(2-hydroxyphenyl)-2-propen-1-ones...

Anti-inflammatory and analgesic activities of some newly synthesized pyridinedicarbonitrile and benzopyranopyridine derivatives

Publié en ligne: 30 mai 2008

Pages: 175 - 186

DOI: https://doi.org/10.2478/v10007-008-0005-4

Mots clés
piridindikarbonitril, benzopiranopiridin, spojevi s protuupalnim i analgetskim djelovanjem

This content is open access.

Anti-inflammatory and analgesic activities of some newly synthesized pyridinedicarbonitrile and benzopyranopyridine derivatives

Publié en ligne: 30 mai 2008

Pages: 175 - 186

DOI: https://doi.org/10.2478/v10007-008-0005-4

Mots cléspiridindikarbonitril, benzopiranopiridin, spojevi s protuupalnim i analgetskim djelovanjem

This content is open access.

Mots clés
piridindikarbonitril, benzopiranopiridin, spojevi s protuupalnim i analgetskim djelovanjem