<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>In this study, we synthesized some new substituted steroidal derivatives using 3β-hydroxyandrosten-17-one (dehydroepiandrosterone) as starting material. The synthesized steroidal derivatives <bold>1-11</bold> were evaluated for their androgenic-anabolic activities compared to testosterone as positive control. Details of the synthesis, spectroscopic data and toxicity (<italic>LD</italic><sub>50</sub>) of synthesized compounds are reported.</p></abstract>

In this study, we synthesized some new substituted steroidal derivatives using 3β-hydroxyandrosten-17-one (dehydroepiandrosterone) as starting material. The synthesized steroidal derivatives 1-11 were evaluated for their androgenic-anabolic activities compared to testosterone as positive control. Details of the synthesis, spectroscopic data and toxicity (LD50) of synthesized compounds are reported.

New steroidal derivatives synthesized using 3β-hydroxyandrosten-17-one as starting material

Natural Compounds Department, National Research Center, Cairo Dokki, Egypt

Research Units, Hi-Care Pharmaceutical Co., Cairo, Egypt

Applied Organic Chemistry Department, National Research Center, Cairo, Dokki, Egypt

Acta Pharmaceutica

In this study, we synthesized some new substituted steroidal derivatives using 3β-hydroxyandrosten-17-one (dehydroepiandrosterone) as starting material. The...

New steroidal derivatives synthesized using 3β-hydroxyandrosten-17-one as starting material

Publié en ligne: 12 mars 2008

Pages: 43 - 59

DOI: https://doi.org/10.2478/v10007-007-0044-2

Mots clés
dehidroepiandrosteron, steroidni derivati, androgeno-anabolički steroidi

This content is open access.

New steroidal derivatives synthesized using 3β-hydroxyandrosten-17-one as starting material

Publié en ligne: 12 mars 2008

Pages: 43 - 59

DOI: https://doi.org/10.2478/v10007-007-0044-2

Mots clésdehidroepiandrosteron, steroidni derivati, androgeno-anabolički steroidi

This content is open access.

Mots clés
dehidroepiandrosteron, steroidni derivati, androgeno-anabolički steroidi