<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Some new hydrazono <bold>5a,b</bold>, thiosemicarbazono <bold>6a-c</bold>, and oximo chromenes <bold>7a-c</bold> were prepared <italic>via</italic> the reaction of the corresponding β-chlorocarbaldehyde <bold>3</bold> with hydrazine, aromatic hydrazine, thiosemicarbazide and hydroxylamine hydrochloride, respectively. In addition, ether derivatives <bold>8a-h</bold> were prepared from the corresponding aldoximes <bold>7a-c</bold>. The new products were tested for anti-inflammatory and ulcerogenic score activities compared to indomethacin.</p></abstract>

Some new hydrazono 5a,b, thiosemicarbazono 6a-c, and oximo chromenes 7a-c were prepared via the reaction of the corresponding β-chlorocarbaldehyde 3 with hydrazine, aromatic hydrazine, thiosemicarbazide and hydroxylamine hydrochloride, respectively. In addition, ether derivatives 8a-h were prepared from the corresponding aldoximes 7a-c. The new products were tested for anti-inflammatory and ulcerogenic score activities compared to indomethacin.

Synthesis and pharmacological activities of some condensed 4-chloro-2,2-dialkyl chromene-3-carbaldehyde derivatives

Photochemistry Department, National Research Centre, Cairo, Egypt

Acta Pharmaceutica

Some new hydrazono 5a,b, thiosemicarbazono 6a-c, and oximo chromenes 7a-c were prepared via the reaction of the corresponding β-chlorocarbaldehyde 3 with...

Synthesis and pharmacological activities of some condensed 4-chloro-2,2-dialkyl chromene-3-carbaldehyde derivatives

Publié en ligne: 12 mars 2008

Pages: 15 - 27

DOI: https://doi.org/10.2478/v10007-007-0042-4

Mots clés
β-klorkarbaldehid, hidrazoni, tiosemikarbazoni, oksim-eteri, protuupalno, ulcerogeno djelovanje

This content is open access.

Synthesis and pharmacological activities of some condensed 4-chloro-2,2-dialkyl chromene-3-carbaldehyde derivatives

Publié en ligne: 12 mars 2008

Pages: 15 - 27

DOI: https://doi.org/10.2478/v10007-007-0042-4

Mots clésβ-klorkarbaldehid, hidrazoni, tiosemikarbazoni, oksim-eteri, protuupalno, ulcerogeno djelovanje

This content is open access.

Mots clés
β-klorkarbaldehid, hidrazoni, tiosemikarbazoni, oksim-eteri, protuupalno, ulcerogeno djelovanje