<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>The objective of the present research was to develop a bilayer tablet of propranolol hydrochloride using superdisintegrant sodium starch glycolate for the fast release layer and water immiscible polymers such as ethylcellulose, Eudragit RLPO and Eudragit RSPO for the sustaining layer. In vitro dissolution studies were carried out in a USP 24 apparatus I. The formulations gave an initial burst effect to provide the loading dose of the drug followed by sustained release for 12 h from the sustaining layer of matrix embedded tablets. In vitro dissolution kinetics followed the Higuchi model via a non-Fickian diffusion controlled release mechanism after the initial burst release. FT-IR studies revealed that there was no interaction between the drug and polymers used in the study. Statistical analysis (ANOVA) showed no significant difference in the cumulative amount of drug release after 15 min, but significant difference (p &lt; 0.05) in the amount of drug released after 12 h from optimized formulations was observed.</p></abstract>

The objective of the present research was to develop a bilayer tablet of propranolol hydrochloride using superdisintegrant sodium starch glycolate for the fast release layer and water immiscible polymers such as ethylcellulose, Eudragit RLPO and Eudragit RSPO for the sustaining layer. In vitro dissolution studies were carried out in a USP 24 apparatus I. The formulations gave an initial burst effect to provide the loading dose of the drug followed by sustained release for 12 h from the sustaining layer of matrix embedded tablets. In vitro dissolution kinetics followed the Higuchi model via a non-Fickian diffusion controlled release mechanism after the initial burst release. FT-IR studies revealed that there was no interaction between the drug and polymers used in the study. Statistical analysis (ANOVA) showed no significant difference in the cumulative amount of drug release after 15 min, but significant difference (p < 0.05) in the amount of drug released after 12 h from optimized formulations was observed.

Design and evaluation of sustained release bilayer tablets of propranolol hydrochloride

P. G. Department of Pharmaceutics, College of Pharmaceutical Sciences, Berhampur-760002 Orissa, India

Acta Pharmaceutica

The objective of the present research was to develop a bilayer tablet of propranolol hydrochloride using superdisintegrant sodium starch glycolate for the fast...

Design and evaluation of sustained release bilayer tablets of propranolol hydrochloride

Publié en ligne: 28 déc. 2007

Pages: 479 - 489

DOI: https://doi.org/10.2478/v10007-007-0038-0

Mots clés
propranolol hidroklorid, dvoslojne tablete, škrob glikolat natrij, polimeri koji se ne miješaju s vodom, statistička analiza

This content is open access.

Design and evaluation of sustained release bilayer tablets of propranolol hydrochloride

Publié en ligne: 28 déc. 2007

Pages: 479 - 489

DOI: https://doi.org/10.2478/v10007-007-0038-0

Mots cléspropranolol hidroklorid, dvoslojne tablete, škrob glikolat natrij, polimeri koji se ne miješaju s vodom, statistička analiza

This content is open access.

Mots clés
propranolol hidroklorid, dvoslojne tablete, škrob glikolat natrij, polimeri koji se ne miješaju s vodom, statistička analiza