<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Chitosan based metronidazole (MZ) inserts were fabricated by the casting method and characterized with respect to mass and thickness uniformity, metronidazole loading and <italic>in vitro</italic> metronidazole release kinetics. The fabricated inserts exhibited satisfactory physical characteristics. The mass of inserts was in the range of 5.63 ± 0.42 to 6.04 ± 0.89 mg. The thickness ranged from 0.46 ± 0.06 to 0.49 ± 0.08 mm. Metronidazole loading was in the range of 0.98 ± 0.09 to 1.07 ± 0.07 mg except for batch CM3 with MZ loading of 2.01 ± 0.08 mg. The inserts exhibited an initial burst release at the end of 24 h, irrespective of the drug to polymer ratio, plasticizer content or cross-linking. However, further drug release was sustained over the next 6 days. Cross-linking with 10% (<italic>m/m</italic>) of glutaraldehyde inhibited the burst release by ~30% and increased the mean dissolution time (MDT) from 0.67 to 8.59 days. The decrease in drug release was a result of reduced permeability of chitosan due to cross-linking.</p></abstract>

Chitosan based metronidazole (MZ) inserts were fabricated by the casting method and characterized with respect to mass and thickness uniformity, metronidazole loading and in vitro metronidazole release kinetics. The fabricated inserts exhibited satisfactory physical characteristics. The mass of inserts was in the range of 5.63 ± 0.42 to 6.04 ± 0.89 mg. The thickness ranged from 0.46 ± 0.06 to 0.49 ± 0.08 mm. Metronidazole loading was in the range of 0.98 ± 0.09 to 1.07 ± 0.07 mg except for batch CM3 with MZ loading of 2.01 ± 0.08 mg. The inserts exhibited an initial burst release at the end of 24 h, irrespective of the drug to polymer ratio, plasticizer content or cross-linking. However, further drug release was sustained over the next 6 days. Cross-linking with 10% (m/m) of glutaraldehyde inhibited the burst release by ~30% and increased the mean dissolution time (MDT) from 0.67 to 8.59 days. The decrease in drug release was a result of reduced permeability of chitosan due to cross-linking.

Chitosan inserts for periodontitis: Influence of drug loading, plasticizer and crosslinking on <italic>in vitro</italic> metronidazole release

Department of Pharmaceutics Institute of Technology, Banaras Hindu University, Varanasi-221005, India

Department of Microbiology Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, India

Faculty of Dental Sciences Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, India

Acta Pharmaceutica

Chitosan inserts for periodontitis: Influence of drug loading, plasticizer and crosslinking on  metronidazole release

Chitosan based metronidazole (MZ) inserts were fabricated by the casting method and characterized with respect to mass and thickness uniformity, metronidazole...

Chitosan inserts for periodontitis: Influence of drug loading, plasticizer and crosslinking on in vitro metronidazole release

Publié en ligne: 28 déc. 2007

Pages: 469 - 477

DOI: https://doi.org/10.2478/v10007-007-0037-1

Mots clés
kitozanski umetci, umrežavanje, metronidazol, periodontitis, polagano oslobađanje

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