Ketorolac-dextran conjugates: Synthesis, in vitro and in vivo evaluation

D. R. Brocks and F. Jamali, Pharmacokinetics of ketorolac tromethamine, Clin. Pharmacokin.23 (1992) 415-427.10.2165/00003088-199223060-00003Search in Google Scholar

W. Wagner, P. Khanna and D. E. Furst, Nonsteroidal Anti-inflammatory Drugs, Disease-modifying Antirheumatic Drugs, Nonopioid Analgesics and Drugs Used in Gout, in Basic and Clinical Pharmacology (Ed. B. G. Katzung), 9^th ed., McGraw-Hill, New York 2004, pp. 586.Search in Google Scholar

V. Cioli, S. Putzolu, V. Rossi, P. S. Barcellona and C. Corradino, The role of direct tissue contact in the production of gastro-intestinal ulcers by anti-inflammatory drugs in rats, Toxicol. Appl. Pharmacol.50 (1979) 283-289; DOI: 10.1016/0041-008X(79)90153-4.10.1016/0041-008X(79)90153-4Search in Google Scholar

K. D. Rainsford, Mechanisms of gastrointestinal toxicity of non-steoridal anti-inflammatory drugs, Scand. J. Gastroenterol. Suppl.163 (1989) 9-16.10.3109/00365528909091169Search in Google Scholar

C. Hawkey, L. Laine, T. Simon, A. Beaulieu, J. Maldonado-Cocco, E. Acevedo, A. Shahane, H. Quan, J. Bolognese and E. Mortensen, Comparison of the effect of rofecoxib, ibuprofen and placebo on the gastroduodenal mucosa of patients with osteoarthritis: A randomized, double blind, placebo-controlled trial, Arthritis Rheum.43 (2000) 370-377; DOI: 10.1002/1529-0131(200002)43:2<370::AID-ANR17>3.0.CO;2-D.10.1002/1529-0131(200002)43:2<370::AID-ANR17>3.0.CO;2-DSearch in Google Scholar

G. Giammona, G. Puglisi, B. Carlisi, A. S. Pignatello and A. Caruso, Polymeric prodrug: α,β polymeric (N-hydroxyethyl)-DL-aspartamide as a macromolecular carrier for non-steroidal anti-inflammatory agents, Int. J. Pharm.57 (1989) 55-62; DOI: 10.1016/0378-5173(89)90263-9.10.1016/0378-5173(89)90263-9Search in Google Scholar

E. Roseeuw, V. Coessens, E. Schacht, B. Vrooman, D. Domurado and G. Marchall, Polymeric prodrugs of antibiotics with improved efficiency, J. Mater. Sci. Mater. Med.10 (1999) 743-746; DOI: 10.1023/A:1008991508877.10.1023/A:1008991508877Search in Google Scholar

M. Zovko, B. Zorc, P. Novak, P. Tepeš, B. Cetina-Čizmek and M. Horvat, Macromolecular prodrugs XI. Synthesis and characterization of polymer-estradiol conjugate, Int. J. Pharm.285 (2004) 35-41; DOI: 10.1016/j.ijpharm.2004.07.013.10.1016/j.ijpharm.2004.07.013Search in Google Scholar

K. Hoste, K. De Winne and E. Schacht, Polymeric prodrugs, Int. J. Pharm.277 (2004) 119-131; DOI: 10.1016/j.ijpharm.2003.07.016.10.1016/j.ijpharm.2003.07.016Search in Google Scholar

A. D. Virnik, K. P. Khomvakov and I. F. Skokova, Dextran and its derivatives, Russ. Chem. Rev.44 (1975) 588-602; DOI: 10.1070/RC1975v044n07ABEH002363.10.1070/RC1975v044n07ABEH002363Search in Google Scholar

C. Larsen, Dextran prodrugs - structure and stability in relation to therapeutic activity, Adv. Drug Deliv. Rev.3 (1989) 103-116; DOI: 10.1016/0169-409X(89)90006-9.10.1016/0169-409X(89)90006-9Search in Google Scholar

C. Larsen and M. Johansen, Macromolecular prodrugs XI: Regeneration rates of various NSAID compounds from their corresponding dextran ester prodrugs in aqueous buffer and in different biological media, Acta. Pharm. Nord.2 (1989) 57-65.Search in Google Scholar

C. Larsen and M. Johansen, Macromolecular prodrugs I. Kinetics and mechanism of hydrolysis of O-benzoyl dextran conjugates in aqueous buffer and human plasma, Int. J. Pharm.27 (1985) 205-218; DOI: 10.1016/0378-5173(85)90070-5.10.1016/0378-5173(85)90070-5Search in Google Scholar

S. Ahmad, R. F. Tester, A. Corbett and J. Karkalas, Dextran and 5-aminosalicylic acid (5-ASA) conjugates: synthesis, characterisation and enzymic hydrolysis, Carbohydr. Res.341 (2006) 2694-2701; DOI: 10.1016/j.carres.2006.08.015.10.1016/j.carres.2006.08.01516973138Search in Google Scholar

S. K. Shrivastava, D. K. Jain and P. Trivedi, Dextrans-potential polymeric drug carriers for flurbiprofen, Pharmazie58 (2003) 389-391.Search in Google Scholar

A. J. Hao, Y. D. Deng, X. B. Suo and Y. H. Cao, Synthesis and characteristics of the fluorouracildextran conjugates, Pharmazie61 (2006) 489-490.Search in Google Scholar

P. Bue, A. R. Holmberg, M. Márquez, J. E. Westlin, S. Nilsson and P. U. Malmstrom, Intravesical administration of EGF-dextran conjugates in patients with superficial bladder cancer, Eur. Urol.38 (2000) 584-589; DOI: 10.1159/000020335.10.1159/00002033511096240Search in Google Scholar

G. S. Mishra, Molecular Weight Determination, in Introductory Polymer Chemistry, 1^st ed., Wiley Eastern Ltd., New Delhi 1993, pp. 99-117.Search in Google Scholar

M. N. Ghosh, Some Common Evaluation Technics, in Fundamentals of Experimental Pharmacology, 2^nd ed., Scientific Book Agency, Calcutta 1984, pp.144-151.Search in Google Scholar

C. A. Winter, E. A. Risley and G. W. Nuss, Carrageenin-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs, Proc Soc. Exp. Biol. Med.111 (1962) 544-547.10.3181/00379727-111-2784914001233Search in Google Scholar

V. R. Shanbhag, A. M. Crider, R. Gokhale, A. Harpalani and R. M. Dick, Ester and amide prodrugs of ibuprofen and naproxen: synthesis, anti-inflammatory activity, and gastrointestinal toxicity, J. Pharm. Sci.81 (1992)149-154; DOI: 10.1002/jps.2600810210.10.1002/jps.26008102101545354Search in Google Scholar