<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>The binary system of etoricoxib with β-cyklodextrin (β-CD) was prepared by the kneading method. Drug-cyclodextrin interactions in solution were investigated by the phase solubility analysis. Differential scanning calorimetry, infrared spectroscopy, powder X-ray diffractometry and microscopic study were used to characterize the solid state of all binary systems, whereas their dissolution properties were evaluated according to the USP XXIII paddle method. The results indicate partial interaction of the drug with β-CD in the physical mixture and complete interaction in the kneaded complex. The dissolution of etoricoxib was notably increased as compared to pure drug as well as its physical mixture. The complex showed more than 75% drug released in 30 min.</p></abstract>

The binary system of etoricoxib with β-cyklodextrin (β-CD) was prepared by the kneading method. Drug-cyclodextrin interactions in solution were investigated by the phase solubility analysis. Differential scanning calorimetry, infrared spectroscopy, powder X-ray diffractometry and microscopic study were used to characterize the solid state of all binary systems, whereas their dissolution properties were evaluated according to the USP XXIII paddle method. The results indicate partial interaction of the drug with β-CD in the physical mixture and complete interaction in the kneaded complex. The dissolution of etoricoxib was notably increased as compared to pure drug as well as its physical mixture. The complex showed more than 75% drug released in 30 min.

Preparation and characterization of etoricoxib-β-cyclodextrin complexes prepared by the kneading method

Department of Quality Assurance, L. M. College of Pharmacy, Navrangpura, Ahmedabad-380009 India

Acta Pharmaceutica

The binary system of etoricoxib with β-cyklodextrin (β-CD) was prepared by the kneading method. Drug-cyclodextrin interactions in solution were investigated by...

Preparation and characterization of etoricoxib-β-cyclodextrin complexes prepared by the kneading method

Publié en ligne: 18 sept. 2007

Pages: 351 - 359

DOI: https://doi.org/10.2478/v10007-007-0028-2

Mots clés
etorikoksib, ciklodekstrin, kompleksacija, metoda gnječenja

This content is open access.

Preparation and characterization of etoricoxib-β-cyclodextrin complexes prepared by the kneading method

Publié en ligne: 18 sept. 2007

Pages: 351 - 359

DOI: https://doi.org/10.2478/v10007-007-0028-2

Mots clésetorikoksib, ciklodekstrin, kompleksacija, metoda gnječenja

This content is open access.

Mots clés
etorikoksib, ciklodekstrin, kompleksacija, metoda gnječenja