Swelling behavior and release properties of pH-sensitive hydrogels based on methacrylic derivatives

N. A. Peppas and W. Leobandung, Stimuli-sensitive hydrogels: ideal carriers for chronobiology and chronotherapy, J. Biomat. Sci. Polymer Ed.15 (2004) 125--144; DOI: 10.1163/156856204322793539.10.1163/156856204322793539Search in Google Scholar

B. Lele and A. Hoffman, Bioadhesive properties of pegylated nanoparticles, J. Control. Rel.69 (2000) 237--248; DOI: 10.1016/S0168-3659(00)00303-5.10.1016/S0168-3659(00)00303-5Search in Google Scholar

A. Clausen and A. Bernkop-Schnürch, Direct compressible polymethacrylic acid-starch compositions for site specific drug delivery, J. Control. Rel.75 (2001) 93--102; DOI:10.1016/S0168-3659 (01)00366-2.Search in Google Scholar

M. Deshpande, M. Davies, M. Garnett, P. Williams, D. Armitage, L. Bailey, M. Vamvakaki, S. Armes and S. Stolnik, The effect of poly(ethylene glycol) molecular architecture on cellular interaction and uptake of DNA complexes, J. Control. Rel.97 (2004) 143--156; DOI:10.1016/j.jconrel. 2004.02.019.Search in Google Scholar

I. Porcar, P. Perrin and C. Tribet, UV-visible light: a novel route to tune the type of an emulsion, Langmuir17 (2001) 6905--6909.Search in Google Scholar

D. Solberg and L. Wegberg, Adsorption and flocculation behavior of cationic polyacrylamide and colloidal silica, Colloids Surf.A 219 (2003) 161--172.Search in Google Scholar

G. Chitanu and A. Carpov, Ecologically benign polymers: The case of maleic polyelectrolytes, Environ. Sci. Technol.36 (2002) 1856--1860.10.1021/es010094sSearch in Google Scholar

A. Taubert, C. Kübel and D. Martin, Polymer induced microstructure variation in zinc oxide crystals precipitated from aqueous solution, J. Phys. Chem.B 107 (2003) 2660--2666; DOI: 10.1021/jp020569h S1089-5647(02)00569-2.10.1021/jp020569hSearch in Google Scholar

A. M. Lowman, M. Morishita, M. Kajita, T. Nagai and N. A. Peppas, Oral delivery of insulin using pH-responsive complexation gels, J. Pharm. Sci.88 (1999) 933--937; DOI: 10.1021/js980337n.10.1021/js980337nSearch in Google Scholar

B. O. Haglund, R. J. Kenneth and J. Himmelstein, An in situ gelling system for parenteral delivery, J. Control. Rel.41 (1996) 229--235; DOI: 10.1016/0168-3659(96)01333-8.10.1016/0168-3659(96)01333-8Search in Google Scholar

N. A. Peppas and A. R. Khare, Preparation, structure and diffusional behaviour of hydrogels in controlled release, Adv. Drug. Del. Rev.11 (1993) 1--35.Search in Google Scholar

A. Gallardo and J. S. Roman, Synthesis and characterization of a new poly(methacrylamide) bearing side groups of biomedical interest, Polymer34 (1993) 394--400.Search in Google Scholar

H. E. Paulus and M. W. Whitehouse, Nonsteroid anti-inflammatory agents, Ann. Rev. Pharmacol. Toxicol.13 (1973) 107--125.Search in Google Scholar

R. Nickander, F. G. McMahon and A. S. Ridolfo, Nonsteroidal anti-inflammatory agents, Ann. Rev. Pharmacol. Toxicol.19 (1979) 469--490.10.1146/annurev.pa.19.040179.002345Search in Google Scholar

S. S. Adams and J. W. Buckler, The Propionic Acids, in Antirheumatic Drugs (Ed. E. C. Huskisson), Praeger Scientific, Eastbourne 1983.Search in Google Scholar

B. Kim and N. A. Peppas, Poly(ethylene glycol)-containing hydrogels for oral protein delivery applications, Biomed. Microdev.3 (2003) 333--341; DOI:10.1002/pts.766.10.1002/pts.766Search in Google Scholar

United States Pharmacopeia 26/National Formulary 21, US Pharmacopeial Convention, Rockwille 1999, pp. 2130--2143.Search in Google Scholar

B. Kim and N. A. Peppas, Synthesis and characterization of pH-sensitive glycopolymers for oral drug delivery systems, J. Biomater. Sci. Polym. Ed.13 (2002) 1271--1281; DOI: 10.1163/156856202320893000.10.1163/156856202320893000Search in Google Scholar

M. Zerrari, Synthèse et Caractérisation des Systèmes de Libération à Base de Poly(ethylene glycol), Master Thesis, Ferhat Abbas University, Sétif Algeria, 2004.Search in Google Scholar

S. Holappa, Complexation of Poly(ethylene Oxide)-Block-Poly(methacrylic acid) in Aqueous Medium, Dissertation, University of Helsinki, Helsinki 2005.Search in Google Scholar

B. Kim and N. A. Peppas, Complexation phenomena in pH-responsive copolymer networks with pendent saccharides, Macromolecules35 (2002) 9545--9560.Search in Google Scholar

P. L. Rittger and N. A. Peppas, A simple equation for description of solute release. II. Fickian and anomalous release from swellable devices, J. Control. Rel.5 (1987) 37--42; DOI: 10.1016/0168-3659(87)90035-6.10.1016/0168-3659(87)90035-6Search in Google Scholar

A. R. Berens and H. B. Hopfenberg, Diffusion and relaxation in glassy polymer powders 2. Separation of diffusion and relaxation parameters, Polymer19 (1978) 489--496.Search in Google Scholar

S. S. Shah, M. G. Kulkarni and R. A. Mashelkar, Release kinetics of pendant substituted bioactive molecules from swellable hydrogels: role of chemical reaction and diffusive transport, J. Membr. Sci.51 (1990) 83--95.Search in Google Scholar

S. S. Shah, M. G. Kulkarni and R. Mashelkar, A mechanistic interpretation of the zero order release from pendant chain-linked glassy and swollen hydrogels, J. Appl. Polym. Sci.41 (1991) 2437--2451.Search in Google Scholar

M. Torres-Lugo, M. Garc'a, R. Record and N. A. Peppas, Physicochemical behavior and cytotoxic effects of p(methacrylic acid-g-ethylene glycol) nanoparticles for oral delivery of proteins, J. Control. Rel.80 (2002) 197--208; DOI: 10.1016/S0168-3659(02)00027-5.10.1016/S0168-3659(02)00027-5Search in Google Scholar

C. G. Pitt, and S. S. Shah, The kinetics of drug cleavage and release from matrices containing covalent polymer-drug conjugates, J. Control Rel.33 (1995) 391--395; DOI: 10.1016/0168-3659 (94)00113-9Search in Google Scholar

B. Kim and N. A. Peppas, Analysis of molecular interactions in P(MAA-g-EG) hydrogels, Polymer44 (2003) 3701--3707; DOI: 10.1016/S0032-3861(03)00307-0.10.1016/S0032-3861(03)00307-0Search in Google Scholar