<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>In this study, attempts were made to investigate the effects of β-cyclodextrin (β-CD) on the aqueous solubility and dissolution rate of celecoxib. Inclusion complexes were prepared by the kneading method and characterized by SEM, NMR, IR, DSC, and X-ray powder diffraction. Dissolution rate of the complexes was significantly greater than that of the corresponding physical mixtures and pure drug, indicating that the formation of inclusion complex increased the solubility of the poorly soluble drug celecoxib.</p></abstract>

In this study, attempts were made to investigate the effects of β-cyclodextrin (β-CD) on the aqueous solubility and dissolution rate of celecoxib. Inclusion complexes were prepared by the kneading method and characterized by SEM, NMR, IR, DSC, and X-ray powder diffraction. Dissolution rate of the complexes was significantly greater than that of the corresponding physical mixtures and pure drug, indicating that the formation of inclusion complex increased the solubility of the poorly soluble drug celecoxib.

Physicochemical characterization and <italic>in vitro</italic> dissolution behaviour of celecoxib-β-cyclodextrin inclusion complexes

University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh India

Department of Chemistry, Panjab University, Chandigarh, India

Acta Pharmaceutica

Physicochemical characterization and  dissolution behaviour of celecoxib-β-cyclodextrin inclusion complexes

In this study, attempts were made to investigate the effects of β-cyclodextrin (β-CD) on the aqueous solubility and dissolution rate of celecoxib. Inclusion...

Physicochemical characterization and in vitro dissolution behaviour of celecoxib-β-cyclodextrin inclusion complexes

Publié en ligne: 28 févr. 2007

Pages: 47 - 60

DOI: https://doi.org/10.2478/v10007-007-0004-x

Mots clés
celecoxib, β-cyclodextrin, inclusion complex, dissolution profile

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