Anticholinergic burden and most common anticholinergic-acting medicines in older general practice patients
, et | 21 juin 2018
À propos de cet article
Article Category: Original scientific article
Publié en ligne: 21 juin 2018
Pages: 140 - 147
Reçu: 22 août 2017
Accepté: 14 mai 2018
DOI: https://doi.org/10.2478/sjph-2018-0018
Mots clés
© 2018 National Institute of Public Health, Slovenia, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Dosing regimen for some of the most common anticholinergic medicines.
| Medicine | Dose and frequency | N of cases |
|---|---|---|
| 2mg daily | 2 | |
| 5 mg daily | 2 | |
| 5mg once to three times weekly | 5 | |
| 5 mg twice monthly | 1 | |
| 25 mg once daily | 7 | |
| 100 mg once daily | 1 | |
| 400 mg once daily | 1 | |
| 150 mg once daily | 8 | |
| 300 mg once daily | 1 | |
| 25 mg once daily | 4 | |
| 25 mg two to three times daily | 2 |
Descriptive statistics.
| Characteristic | |
|---|---|
| • Male | 266 (42.8%) |
| • Female | 356 (57.2%) |
| 77.2 (±6.2) | |
| • Range (years) | 65-101 |
| 5.6 (±2.9) | |
| 374 (60.1%) |
Anticholinergic burden in patients with anticholinergic medicines (N=78).
| Anticholinergic burden (score) | N (%) of patients with anticholinergic medicines |
|---|---|
| 54 (69.2%) | |
| 19 (24.4%) | |
| 4 (5.1%) | |
| 1 (1.3%) |
List of anticholinergic medicines in patients with an anticholinergic burden.
| Medicine (ATC code) | N (%) of patients with anticholinergic burden N=78 | % of all enrolled patients N=622 | Anticholinergic burden |
|---|---|---|---|
| 41 (52.6%) | 6.6% | ||
| Diazepam (N05BA01) | 10 (12.8%) | 1.6% | 1 |
| Quetiapine (N05AH04) | 9 (11.5%) | 1.4% | 1 |
| Paroxetine (N06AB05) | 7 (9.0%) | 1.1% | 1 |
| Amitriptilyne (N06AA09) | 6 (7.7%) | 1.0% | 2 |
| Mirtazapine (N06AX11) | 4 (5.1%) | 0.6% | 1 |
| Citalopram (N06AB04) | 4 (5.1%) | 0.6% | 1 |
| Fentanyl (N02AB03) | 2 (2.6%) | 0.3% | 1 |
| Olanzapine (N05AH03) | 2 (2.6%) | 0.3% | 1 |
| Carbamazepine (N03AF01) | 2 (2.6%) | 0.3% | 1 |
| Fluoxetine (N06AB03) | 2 (2.6%) | 0.3% | 1 |
| Risperidone (N05AX08) | 2 (2.6%) | 0.3% | 1 |
| Promazine (N05AA03) | 1 (1.3%) | 0.2% | 1 |
| Clozapine (N05AH02) | 1 (1.3%) | 0.2% | 2 |
| Lithim (N05AN01) | 1 (1.3%) | 0.2% | 1 |
| Trazodone (N06AX05) | 1 (1.3%) | 0.2% | 1 |
| 11 (14.1%) | 1.8% | ||
| Ranitidine (A02BA02) | 8 (10.3%) | 1.3% | 1 |
| Domperidone (A03FA03) | 3 (3.8%) | 0.5% | 1 |
| 11 (14.1%) | 1.8% | ||
| Loratadine (R06AX13) | 4 (5.1%) | 0.6% | 1 |
| Cetirizine (R06AE07) | 3 (3.8%) | 0.5% | 1 |
| Fexofenadine (R06AX26) | 2 (2.6%) | 0.3% | 1 |
| Theophylline (R03DA04) | 2 (2.6%) | 0.3% | 1 |
| 6 (7.7%) | 1.0% | ||
| Tizanidine (M03BX02) | 6 (7.7.%) | 1.0% | 2 |
| 5 (6.4%) | 0.8% | ||
| Darifenacin (G04BD10) | 3 (3.8%) | 0.5% | 2 |
| Tolterodine (G04BD07) | 2 (2.6%) | 0.3% | 2 |
| 1 (1.3%) | 0.2% | ||
| Disopyramide (C01BA03) | 1 (1.3%) | 0.2% | 1 |