This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Fried LP, Xue QL, Cappola AR, Ferrucci L, Chaves P, Varadhan R, et al. Nonlinear multisystem physiological dysregulation associated with frailty in older women: implications for etiology and treatment. J Gerontol A Biol Sci Med Sci. 2009;64(10):1049-57. 10.1093/gerona/glp076.19567825FriedLPXueQLCappolaARFerrucciLChavesPVaradhanRNonlinear multisystem physiological dysregulation associated with frailty in older women: implications for etiology and treatment2009641010495710.1093/gerona/glp076Open DOISearch in Google Scholar
Kehler DS, Ferguson T, Stammers AN, Bohm C, Arora RC, Duhamel TA, et al. Prevalence of frailty in Canadians 18-79 years old in the Canadian Health Measures Survey. BMC Geriatr. 2017;17(1):28. 10.1186/s12877-017-0423-6.28107813KehlerDSFergusonTStammersANBohmCAroraRCDuhamelTAPrevalence of frailty in Canadians 18-79 years old in the Canadian Health Measures Survey20171712810.1186/s12877-017-0423-6Open DOISearch in Google Scholar
Gobbens RJ, van Assen MA, Luijkx KG, Wijnen-Sponselee MT, Schols JM. Determinants of frailty. J Am Med Dir Assoc. 2010;11(5):356-64. 10.1016/j.jamda.2009.11.008.20511103GobbensRJvan AssenMALuijkxKGWijnen-SponseleeMTScholsJM.Determinants of frailty20101153566410.1016/j.jamda.2009.11.008Open DOISearch in Google Scholar
Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci Med Sci. 2004;59(3):255–63. 10.1093/gerona/59.3.M255.15031310FriedLPFerrucciLDarerJWilliamsonJDAndersonG.Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care20045932556310.1093/gerona/59.3.M255Open DOISearch in Google Scholar
Gill TM, Gahbauer EA, Han L, Allore HG. Trajectories of disability in the last year of life. N Engl J Med. 2010;362(13):1173–80. 10.1056/NEJMoa0909087.20357280GillTMGahbauerEAHanLAlloreHG.Trajectories of disability in the last year of life20103621311738010.1056/NEJMoa0909087Open DOISearch in Google Scholar
Welsh TJ, Gordon AL, Gladman JR. Comprehensive geriatric assessment - a guide for the non-specialist. Int J Clin Pract. 2014;68(3):290-3. 10.1111/ijcp.12313.24118661WelshTJGordonALGladmanJR.Comprehensive geriatric assessment - a guide for the non-specialist2014683290310.1111/ijcp.12313Open DOISearch in Google Scholar
Gill TM, Gahbauer EA, Allore HG, Han L. Transitions between frailty states among community-living older persons. Arch Intern Med. 2006;166(4):418-23. 10.1001/archinte.166.4.418.16505261GillTMGahbauerEAAlloreHGHanL.Transitions between frailty states among community-living older persons200616644182310.1001/archinte.166.4.418Open DOISearch in Google Scholar
Akishita M, Ishii S, Kojima T, Kozaki K, Kuzuya M, Arai H, et al. Priorities of health care outcomes for the elderly. J Am Med Dir Assoc. 2013;14(7):479-84. 10.1016/j.jamda.2013.01.009.23415841AkishitaMIshiiSKojimaTKozakiKKuzuyaMAraiHPriorities of health care outcomes for the elderly20131474798410.1016/j.jamda.2013.01.009Open DOISearch in Google Scholar
Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and metaanalysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4(1):1. 10.1186/2046-4053-4-1.25554246MoherDShamseerLClarkeMGhersiDLiberatiAPetticrewMPreferred reporting items for systematic review and metaanalysis protocols (PRISMA-P) 2015 statement201541110.1186/2046-4053-4-1Open DOISearch in Google Scholar
Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001; 56(3):146-56. 10.1093/gerona/56.3.M146.FriedLPTangenCMWalstonJNewmanABHirschCGottdienerJFrailty in older adults: evidence for a phenotype20015631465610.1093/gerona/56.3.M146Open DOISearch in Google Scholar
Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013;381(9868):752-62. 10.1016/S0140-6736(12)62167-9.23395245CleggAYoungJIliffeSRikkertMORockwoodK.Frailty in elderly people201338198687526210.1016/S0140-6736(12)62167-9Open DOISearch in Google Scholar
Abellan van Kan G, Rolland Y, Bergman H, Morley JE, Kritchevsky SB, Vellas B, et al. The I.A.N.A. task force on frailty assessment of older people in clinical practice. J Nutr Health Aging. 2008;12(1):29-37. 10.1007/BF02982161.18165842Abellan van KanGRollandYBergmanHMorleyJEKritchevskySBVellasBThe I.A.N.A. task force on frailty assessment of older people in clinical practice2008121293710.1007/BF02982161Open DOISearch in Google Scholar
Dent E, Kowal P, Hoogendijk EO. Frailty measurement in research and clinical practice: a review. Eur J Intern Med. 2016;31:3-10. 10.1016/j.ejim.2016.03.007.27039014DentEKowalPHoogendijkEO.Frailty measurement in research and clinical practice: a review20163131010.1016/j.ejim.2016.03.007Open DOISearch in Google Scholar
Stoicea N, Baddigam R, Wajahn J, Sipes AC, Arias-Morales CE, Gastaldo N, et al. The gap between clinical research and standard of care: a review of frailty assessment scales in perioperative surgical settings. Front Public Health. 2016;4:150. 10.3389/fpubh.2016.00150.27493935StoiceaNBaddigamRWajahnJSipesACArias-MoralesCEGastaldoNThe gap between clinical research and standard of care: a review of frailty assessment scales in perioperative surgical settings2016415010.3389/fpubh.2016.00150Open DOISearch in Google Scholar
Subra J, Gillette-Guyonnet S, Cesari M, Oustric S, Vellas B, Platform Team. The integration of frailty into clinical practice: preliminary results from the Gérontopôle. J Nutr Health Aging. 2012;16(8):714-20. 10.1007/s12603-012-0391-7.SubraJGillette-GuyonnetSCesariMOustricSVellasBPlatform Team. The integration of frailty into clinical practice: preliminary results from the Gérontopôle20121687142010.1007/s12603-012-0391-7Open DOISearch in Google Scholar
Vellas B, Balardy L, Gillette-Guyonnet S, Abellan Van Kan G, Ghisolfi-Marque A, Subra J, et al. Looking for frailty in community-dwelling older persons: the Gérontopôle Frailty Screening Tool (GFST). J Nutr Health Aging. 2013;17(7):629-31. 10.1007/s12603-013-0363-6.23933875VellasBBalardyLGillette-GuyonnetSAbellan Van KanGGhisolfi-MarqueASubraJLooking for frailty in community-dwelling older persons: the Gérontopôle Frailty Screening Tool (GFST)20131776293110.1007/s12603-013-0363-6Open DOISearch in Google Scholar
Morley JE, Vellas B, Abellan van Kan G, Anker SD, Bauer JM, Bernabei R, et al. Frailty consensus: a call to action. J Am Med Dir Assoc. 2013;14(6):392-7. 10.1016/j.jamda.2013.03.022.MorleyJEVellasBAbellan van KanGAnkerSDBauerJMBernabeiRFrailty consensus: a call to action2013146392710.1016/j.jamda.2013.03.022Open DOISearch in Google Scholar
Sutton JL, Gould RL, Daley S, Coulson MC, Ward EV, Butler AM, et al. Psychometric properties of multicomponent tools designed to assess frailty in older adults: a systematic review. BMC Geriatr. 2016;16:55. 10.1186/s12877-016-0225-2.26927924SuttonJLGouldRLDaleySCoulsonMCWardEVButlerAMPsychometric properties of multicomponent tools designed to assess frailty in older adults: a systematic review2016165510.1186/s12877-016-0225-2Open DOISearch in Google Scholar
Theou O, Stathokostas L, Roland KP, Jakobi JM, Patterson C, Vandervoort AA, et al. The effectiveness of exercise interventions for the management of frailty: a systematic review. J Aging Res. 2011;2011:569194. 10.4061/2011/569194.21584244TheouOStathokostasLRolandKPJakobiJMPattersonCVandervoortAAThe effectiveness of exercise interventions for the management of frailty: a systematic review2011201156919410.4061/2011/569194Open DOISearch in Google Scholar
Beaudart C, Buckinx F, Rabenda V, Gillain S, Cavalier E, Slomian J, et al. The effects of vitamin D on skeletal muscle strength, muscle mass, and muscle power: a systematic review and metaanalysis of randomized controlled trials. J Clin Endocrinol Metab. 2014;99(11):4336-45. 10.1210/jc.2014-1742.BeaudartCBuckinxFRabendaVGillainSCavalierESlomianJThe effects of vitamin D on skeletal muscle strength, muscle mass, and muscle power: a systematic review and metaanalysis of randomized controlled trials2014991143364510.1210/jc.2014-1742Open DOISearch in Google Scholar
Bruyčre O, Cavalier E, Buckinx F, Reginster JY. Relevance of vitamin D in the pathogenesis and therapy of frailty. Curr Opin Clin Nutr Metab Care. 2017;20(1):26-9. 10.1097/MCO.0000000000000334.27749712BruyčreOCavalierEBuckinxFReginsterJY.Relevance of vitamin D in the pathogenesis and therapy of frailty201720126910.1097/MCO.0000000000000334Open DOISearch in Google Scholar
Cesari M, Vellas B, Hsu FC, Newman AB, Doss H, King AC, et al. A physical activity intervention to treat the frailty syndrome in older persons - results from the LIFE-P Study. J Gerontol A Biol Sci Med Sci. 2015;70(2):216-22. 10.1093/gerona/glu099.25387728CesariMVellasBHsuFCNewmanABDossHKingACA physical activity intervention to treat the frailty syndrome in older persons - results from the LIFE-P Study20157022162210.1093/gerona/glu099Open DOISearch in Google Scholar
Ng TP, Feng L, Nyunt MS, Niti M, Tan BY, et al. Nutritional, physical, cognitive, and combination interventions and frailty reversal among older adults: a randomized controlled trial. Am J Med. 2015;128(11):1225-36. 10.1016/j.amjmed.2015.06.017.26159634NgTPFengLNyuntMSNitiMTanBYNutritional, physical, cognitive, and combination interventions and frailty reversal among older adults: a randomized controlled trial20151281112253610.1016/j.amjmed.2015.06.017Open DOISearch in Google Scholar
Song X, Mitnitski A, Rockwood K. Prevalence and 10-year outcomes of frailty in older adults in relation to deficit accumulation. J Am Geriatr Soc. 2010;58(4):681-7. 10.1111/j.1532-5415.2010.02764.x.20345864SongXMitnitskiARockwoodK.Prevalence and 10-year outcomes of frailty in older adults in relation to deficit accumulation2010584681710.1111/j.1532-5415.2010.02764.xOpen DOISearch in Google Scholar
Puts MTE, Toubasi S, Andrew MK, Ashe MC, Ploeg J, Atkinson E, et al. Interventions to prevent or reduce the level of frailty in communitydwelling older adults: a scoping review of the literature and international policies. Age Ageing. 2017;46(3): 383-92. 10.1093/ageing/afw247.PutsMTEToubasiSAndrewMKAsheMCPloegJAtkinsonEInterventions to prevent or reduce the level of frailty in communitydwelling older adults: a scoping review of the literature and international policies20174633839210.1093/ageing/afw247Open DOISearch in Google Scholar
Turner G, Clegg A, British Geriatrics Society, Age UK, Royal College of General Practioners. Best practice guidelines for the management of frailty: a British Geriatrics Society, Age UK and Royal College of General Practitioners report. Age Ageing. 2014;43(6):744-7. 10.1093/ageing/afu138.25336440TurnerGCleggABritish Geriatrics Society, Age UK, Royal College of General Practioners. Best practice guidelines for the management of frailty: a British Geriatrics Society, Age UK and Royal College of General Practitioners report2014436744710.1093/ageing/afu138Open DOISearch in Google Scholar
Collard RM, Boter H, Schoevers RA, Oude Voshaar RC. Prevalence of frailty in community-dwelling older persons: a systematic review. J Am Geriatr Soc. 2012;60(8):1487-92. 10.1111/j.1532-5415.2012.04054.x.CollardRMBoterHSchoeversRAOude VoshaarRC.Prevalence of frailty in community-dwelling older persons: a systematic review201260814879210.1111/j.1532-5415.2012.04054.xOpen DOISearch in Google Scholar
Chan D-DC, Tsou H-H, Yang R-S, Tsauo J-Y, Chen C-Y, Hsiung CA, et al. A pilot randomized controlled trial to improve geriatric frailty. BMC Geriatr. 2012;12:58. 10.1186/1471-2318-12-58.23009149ChanD-DCTsouH-HYangR-STsauoJ-YChenC-YHsiungCAA pilot randomized controlled trial to improve geriatric frailty2012125810.1186/1471-2318-12-58Open DOISearch in Google Scholar
Li CM, Chen CY, Li CY, Wang WD, Wu SC. The effectiveness of a comprehensive geriatric assessment intervention program for frailty in community-dwelling older people: a randomized, controlled trial. Arch Gerontol Geriatr. 2010;50(Suppl 1):S39-42. 10.1016/S0167-4943(10)70011-X.20171455LiCMChenCYLiCYWangWDWuSC.The effectiveness of a comprehensive geriatric assessment intervention program for frailty in community-dwelling older people: a randomized, controlled trial2010501S394210.1016/S0167-4943(10)70011-XOpen DOISearch in Google Scholar
Cameron ID, Fairhall N, Langron C, Lockwood K, Monaghan N, Aggar C, et al. A multifactorial interdisciplinary intervention reduces frailty in older people: randomized trial. BMC Med. 2013;11:65. 10.1186/1741-7015-11-65.23497404CameronIDFairhallNLangronCLockwoodKMonaghanNAggarCA multifactorial interdisciplinary intervention reduces frailty in older people: randomized trial2013116510.1186/1741-7015-11-65Open DOISearch in Google Scholar
Behm L, Eklund K, Wilhelmson K, Zidén L, Gustafsson S, Falk K, et al. Health Promotion can postpone frailty: results from the RCT elderly persons in the risk zone. Public Health Nurs. 2016;33(4):303-15. 10.1111/phn.12240.26568469BehmLEklundKWilhelmsonKZidénLGustafssonSFalkKHealth Promotion can postpone frailty: results from the RCT elderly persons in the risk zone20163343031510.1111/phn.12240Open DOISearch in Google Scholar
Ellis G, Whitehead MA, O’Neill D, Langhorne P, Robinson D. Comprehensive geriatric assessment for older adults admitted to hospital:meta-analysis of randomised controlled trials. BMJ. 2011;343:d6553. https://doi.org/10.1136/bmj.d6553.EllisGWhiteheadMAO’NeillDLanghornePRobinsonD.Comprehensive geriatric assessment for older adults admitted to hospital:meta-analysis of randomised controlled trialshttps://doi.org/10.1136/bmj.d6553Search in Google Scholar
Gill TM, Baker DI, Gottschalk M, Peduzzi PN, Allore H, Van Ness PH. A prehabilitation program for the prevention of functional decline: effect on higher-level physical function. Arch Phys Med Rehabil. 2004;85(7):1043–9. 10.1016/j.apmr.2003.10.021.15241748GillTMBakerDIGottschalkMPeduzziPNAlloreHVan NessPH.A prehabilitation program for the prevention of functional decline: effect on higher-level physical function20048571043910.1016/j.apmr.2003.10.021Open DOISearch in Google Scholar
Rooks D, Praestgaard J, Hariry S, Laurent D, Petricoul O, Perry RG, et al. Treatment of sarcopenia with bimagrumab: results from a phase ii, randomized, controlled, proof-of-concept study. J Am Geriatr Soc. 2017;65(9):1988-95. 10.1111/jgs.14927.28653345RooksDPraestgaardJHarirySLaurentDPetricoulOPerryRGTreatment of sarcopenia with bimagrumab: results from a phase ii, randomized, controlled, proof-of-concept study201765919889510.1111/jgs.14927Open DOISearch in Google Scholar