<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Cytokine-mediated immunity plays an important role in the pathogenesis of the rheumatoid arthritis. Interleukins IL-33 and IL-35 are closely associated with various rheumatic diseases. The effect of IL-33 on rheumatoid arthritis is believed to be mediated by induction of proinflammatory cytokines (IFN-γ, TNF-α, and IL-17), activation of mast cell degranulation, and mobilization of neutrophils in the joints. However, in addition to the pro-inflammatory, its anti-inflammatory role in rheumatic diseases has also been noticed. The potential mechanism of its anti-inflammatory action can be explained by IL-33-induced mast cell activation that can affect rheumatoid arthritis. IL-35 is a heterodimeric protein and has a significant anti-inflammatory effect. This inhibitory cytokine can express its therapeutic potential through the suppression of osteoclastogenesis and angiogenesis. This review presents current knowledge on the role of these cytokines in the pathogenesis of rheumatoid arthritis.</p>
</abstract>

Cytokine-mediated immunity plays an important role in the pathogenesis of the rheumatoid arthritis. Interleukins IL-33 and IL-35 are closely associated with various rheumatic diseases. The effect of IL-33 on rheumatoid arthritis is believed to be mediated by induction of proinflammatory cytokines (IFN-γ, TNF-α, and IL-17), activation of mast cell degranulation, and mobilization of neutrophils in the joints. However, in addition to the pro-inflammatory, its anti-inflammatory role in rheumatic diseases has also been noticed. The potential mechanism of its anti-inflammatory action can be explained by IL-33-induced mast cell activation that can affect rheumatoid arthritis. IL-35 is a heterodimeric protein and has a significant anti-inflammatory effect. This inhibitory cytokine can express its therapeutic potential through the suppression of osteoclastogenesis and angiogenesis. This review presents current knowledge on the role of these cytokines in the pathogenesis of rheumatoid arthritis.

Role of IL-33 and IL-35 in the Pathogenesis of Rheumatoid Arthritis

University of Kragujevac, Faculty of Medical Sciences

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Role of IL-33 and IL-35 in the Pathogenesis of Rheumatoid Arthritis"}

Cytokine-mediated immunity plays an important role in the pathogenesis of the rheumatoid arthritis. Interleukins IL-33 and IL-35 are closely associated with...

Role of IL-33 and IL-35 in the Pathogenesis of Rheumatoid Arthritis

Publié en ligne: 27 janv. 2023

Pages: -

Reçu: 23 janv. 2022

Accepté: 16 mars 2022

DOI: https://doi.org/10.2478/sjecr-2022-0037

Mots clés
IL-33, IL-35, rheumatoid arthritis

© 2023 Jasmina Jocic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Role of IL-33 and IL-35 in the Pathogenesis of Rheumatoid Arthritis

Publié en ligne: 27 janv. 2023

Pages: -

Reçu: 23 janv. 2022

Accepté: 16 mars 2022

DOI: https://doi.org/10.2478/sjecr-2022-0037

Mots clésIL-33, IL-35, rheumatoid arthritis

© 2023 Jasmina Jocic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
IL-33, IL-35, rheumatoid arthritis