<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Preeclampsia (PE) is a major complication of pregnancy with both mother and fetal adverse outcomes. Pregnancy is a state of increased oxidative stress that has been reported to be exacerbated when complicated with preeclampsia. However, conflicting data are available in literature regarding the systemic oxidative stress in PE pregnancies. The present pilot study was purported to assess systemic oxidative stress in preeclamptic vs healthy pregnancies. To this aim plasma derived compounds of reactive oxygen metabolites (d-ROMs) and the biological antioxidant potential (BAP) were determined in mild and severe preeclamptic pregnancies using the Diacron equipment. Both healthy and preeclamptic pregnancies showed high levels of systemic oxidative stress. Paradoxically, significantly higher values of d-ROMs were found in healthy pregnancies as compared to the PE ones. At variance, in preeclamptic pregnancies, a major increase in the plasma antioxidant capacity occurred. In this pilot study, we report an increase in the systemic antioxidant capacity in preeclamptic pregnancies.</p>
</abstract>

Preeclampsia (PE) is a major complication of pregnancy with both mother and fetal adverse outcomes. Pregnancy is a state of increased oxidative stress that has been reported to be exacerbated when complicated with preeclampsia. However, conflicting data are available in literature regarding the systemic oxidative stress in PE pregnancies. The present pilot study was purported to assess systemic oxidative stress in preeclamptic vs healthy pregnancies. To this aim plasma derived compounds of reactive oxygen metabolites (d-ROMs) and the biological antioxidant potential (BAP) were determined in mild and severe preeclamptic pregnancies using the Diacron equipment. Both healthy and preeclamptic pregnancies showed high levels of systemic oxidative stress. Paradoxically, significantly higher values of d-ROMs were found in healthy pregnancies as compared to the PE ones. At variance, in preeclamptic pregnancies, a major increase in the plasma antioxidant capacity occurred. In this pilot study, we report an increase in the systemic antioxidant capacity in preeclamptic pregnancies.

Assessment of the Systemic Oxidative Stress in Preeclampsia

Department III Functional Sciences – Pathophysiology

Department XII – Obstetrics and Gynecology I

Department XII – Obstetrics and Gynecology III

Department IX Surgery I – Surgical Semiotics I

“Victor Babeș” University of Medicine and Pharmacy

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Assessment of the Systemic Oxidative Stress in Preeclampsia"}

Preeclampsia (PE) is a major complication of pregnancy with both mother and fetal adverse outcomes. Pregnancy is a state of increased oxidative stress that has...

Assessment of the Systemic Oxidative Stress in Preeclampsia

Publié en ligne: 07 avr. 2022

Pages: 45 - 50

Reçu: 18 mars 2022

Accepté: 20 mars 2022

DOI: https://doi.org/10.2478/sjecr-2022-0010

Mots clés
preeclampsia, plasma reactive oxygen species, d- ROM, biological antioxidant potential, BAP, Diacron

© 2022 Anca M. Bînă et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Assessment of the Systemic Oxidative Stress in Preeclampsia

Publié en ligne: 07 avr. 2022

Pages: 45 - 50

Reçu: 18 mars 2022

Accepté: 20 mars 2022

DOI: https://doi.org/10.2478/sjecr-2022-0010

Mots cléspreeclampsia, plasma reactive oxygen species, d- ROM, biological antioxidant potential, BAP, Diacron

© 2022 Anca M. Bînă et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
preeclampsia, plasma reactive oxygen species, d- ROM, biological antioxidant potential, BAP, Diacron